A Stromal Niche Defined by Expression of the Transcription Factor WT1 Mediates Programming and Homeostasis of Cavity-Resident Macrophages

Matthew B. Buechler, Ki Wook Kim, Emily J. Onufer, Jesse W. Williams, Christine C. Little, Claudia X. Dominguez, Qingling Li, Wendy Sandoval, Jonathan E. Cooper, Charles A. Harris, Melissa R. Junttila, Gwendalyn J. Randolph, Shannon J. Turley

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20 Scopus citations

Abstract

Buechler et al. show that large cavity macrophages (LCMs), which rely on the retinoic-acid-responsive transcription factor GATA6, are found in all visceral cavity spaces. Wt1+ mesothelial and fibroblastic stromal cells maintain the LCM transcriptome in part via the generation of retinoic acid and are required for LCM homeostasis in vivo.

Original languageEnglish
Pages (from-to)119-130.e5
JournalImmunity
Volume51
Issue number1
DOIs
StatePublished - Jul 16 2019

Keywords

  • Fibroblasts
  • Macrophages
  • Mesothelial cells
  • Retinoic acid
  • WT1

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    Buechler, M. B., Kim, K. W., Onufer, E. J., Williams, J. W., Little, C. C., Dominguez, C. X., Li, Q., Sandoval, W., Cooper, J. E., Harris, C. A., Junttila, M. R., Randolph, G. J., & Turley, S. J. (2019). A Stromal Niche Defined by Expression of the Transcription Factor WT1 Mediates Programming and Homeostasis of Cavity-Resident Macrophages. Immunity, 51(1), 119-130.e5. https://doi.org/10.1016/j.immuni.2019.05.010