A Stromal Niche Defined by Expression of the Transcription Factor WT1 Mediates Programming and Homeostasis of Cavity-Resident Macrophages

Matthew B. Buechler; Ki Wook Kim; Emily J. Onufer; Jesse W. Williams; Christine C. Little; Claudia X. Dominguez; Qingling Li; Wendy Sandoval; Jonathan E. Cooper; Charles A. Harris; Melissa R. Junttila; Gwendalyn J. Randolph; Shannon J. Turley

doi:10.1016/j.immuni.2019.05.010

A Stromal Niche Defined by Expression of the Transcription Factor WT1 Mediates Programming and Homeostasis of Cavity-Resident Macrophages

Matthew B. Buechler, Ki Wook Kim, Emily J. Onufer, Jesse W. Williams, Christine C. Little, Claudia X. Dominguez, Qingling Li, Wendy Sandoval, Jonathan E. Cooper, Charles A. Harris, Melissa R. Junttila, Gwendalyn J. Randolph, Shannon J. Turley

Research output: Contribution to journal › Article › peer-review

101 Scopus citations

Abstract

Buechler et al. show that large cavity macrophages (LCMs), which rely on the retinoic-acid-responsive transcription factor GATA6, are found in all visceral cavity spaces. Wt1+ mesothelial and fibroblastic stromal cells maintain the LCM transcriptome in part via the generation of retinoic acid and are required for LCM homeostasis in vivo.

Original language	English
Pages (from-to)	119-130.e5
Journal	Immunity
Volume	51
Issue number	1
DOIs	https://doi.org/10.1016/j.immuni.2019.05.010
State	Published - Jul 16 2019

Keywords

Fibroblasts
Macrophages
Mesothelial cells
Retinoic acid
WT1

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10.1016/j.immuni.2019.05.010

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Buechler, M. B., Kim, K. W., Onufer, E. J., Williams, J. W., Little, C. C., Dominguez, C. X., Li, Q., Sandoval, W., Cooper, J. E., Harris, C. A., Junttila, M. R., Randolph, G. J., & Turley, S. J. (2019). A Stromal Niche Defined by Expression of the Transcription Factor WT1 Mediates Programming and Homeostasis of Cavity-Resident Macrophages. Immunity, 51(1), 119-130.e5. https://doi.org/10.1016/j.immuni.2019.05.010

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title = "A Stromal Niche Defined by Expression of the Transcription Factor WT1 Mediates Programming and Homeostasis of Cavity-Resident Macrophages",

abstract = "Buechler et al. show that large cavity macrophages (LCMs), which rely on the retinoic-acid-responsive transcription factor GATA6, are found in all visceral cavity spaces. Wt1+ mesothelial and fibroblastic stromal cells maintain the LCM transcriptome in part via the generation of retinoic acid and are required for LCM homeostasis in vivo.",

keywords = "Fibroblasts, Macrophages, Mesothelial cells, Retinoic acid, WT1",

author = "Buechler, {Matthew B.} and Kim, {Ki Wook} and Onufer, {Emily J.} and Williams, {Jesse W.} and Little, {Christine C.} and Dominguez, {Claudia X.} and Qingling Li and Wendy Sandoval and Cooper, {Jonathan E.} and Harris, {Charles A.} and Junttila, {Melissa R.} and Randolph, {Gwendalyn J.} and Turley, {Shannon J.}",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",

year = "2019",

month = jul,

day = "16",

doi = "10.1016/j.immuni.2019.05.010",

language = "English",

volume = "51",

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journal = "Immunity",

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Buechler, MB, Kim, KW, Onufer, EJ, Williams, JW, Little, CC, Dominguez, CX, Li, Q, Sandoval, W, Cooper, JE, Harris, CA, Junttila, MR, Randolph, GJ & Turley, SJ 2019, 'A Stromal Niche Defined by Expression of the Transcription Factor WT1 Mediates Programming and Homeostasis of Cavity-Resident Macrophages', Immunity, vol. 51, no. 1, pp. 119-130.e5. https://doi.org/10.1016/j.immuni.2019.05.010

TY - JOUR

T1 - A Stromal Niche Defined by Expression of the Transcription Factor WT1 Mediates Programming and Homeostasis of Cavity-Resident Macrophages

AU - Buechler, Matthew B.

AU - Kim, Ki Wook

AU - Onufer, Emily J.

AU - Williams, Jesse W.

AU - Little, Christine C.

AU - Dominguez, Claudia X.

AU - Li, Qingling

AU - Sandoval, Wendy

AU - Cooper, Jonathan E.

AU - Harris, Charles A.

AU - Junttila, Melissa R.

AU - Randolph, Gwendalyn J.

AU - Turley, Shannon J.

PY - 2019/7/16

Y1 - 2019/7/16

N2 - Buechler et al. show that large cavity macrophages (LCMs), which rely on the retinoic-acid-responsive transcription factor GATA6, are found in all visceral cavity spaces. Wt1+ mesothelial and fibroblastic stromal cells maintain the LCM transcriptome in part via the generation of retinoic acid and are required for LCM homeostasis in vivo.

AB - Buechler et al. show that large cavity macrophages (LCMs), which rely on the retinoic-acid-responsive transcription factor GATA6, are found in all visceral cavity spaces. Wt1+ mesothelial and fibroblastic stromal cells maintain the LCM transcriptome in part via the generation of retinoic acid and are required for LCM homeostasis in vivo.

KW - Fibroblasts

KW - Macrophages

KW - Mesothelial cells

KW - Retinoic acid

KW - WT1

UR - http://www.scopus.com/inward/record.url?scp=85068223107&partnerID=8YFLogxK

U2 - 10.1016/j.immuni.2019.05.010

DO - 10.1016/j.immuni.2019.05.010

M3 - Article

C2 - 31231034

AN - SCOPUS:85068223107

SN - 1074-7613

VL - 51

SP - 119-130.e5

JO - Immunity

JF - Immunity

IS - 1

ER -

A Stromal Niche Defined by Expression of the Transcription Factor WT1 Mediates Programming and Homeostasis of Cavity-Resident Macrophages

Abstract

Keywords

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