A strategy combining imaging and laboratory biomarkers in comparison with a simplified clinical score for risk stratification of patients with acute pulmonary embolism

Mareike Lankeit, Vicente Gómez, Carolin Wagner, Drahomir Aujesky, Mónica Recio, Sem Briongos, Lisa K. Moores, Roger D. Yusen, Stavros Konstantinides, David Jiménez

Research output: Contribution to journalArticlepeer-review

68 Scopus citations

Abstract

Background: This study aimed to assess the performance of two prognostic models - the European Society of Cardiology (ESC) model and the simplified Pulmonary Embolism Severity Index (sPESI) - in predicting short-term mortality in patients with pulmonary embolism (PE). Methods: We compared the test characteristics of the ESC model and the sPESI for predicting 30-day outcomes in a cohort of 526 patients with objectively confirmed PE. The primary end point of the study was all-cause mortality. The secondary end point included all-cause mortality, nonfatal symptomatic recurrent VTE, or nonfatal major bleeding. Results: Overall, 40 of 526 patients died (7.6%; 95% CI, 5.3%-9.9%) during the first month of follow-up. The sPESI classified fewer patients as low risk (31% [165 of 526], 95% CI, 27%-35%) compared with the ESC model (39% [207 of 526], 95% CI, 35% to 44%; P < .01). Importantly however, low-risk patients based on the sPESI had no 30-day mortality compared with 3.4% (95% CI, 0.9-5.8) in low-risk patients by the ESC model. The secondary end point occurred in 1.8% of patients in the sPESI low-risk and 5.8% in the ESC low-risk group (difference, 4.0 percentage points; 95% CI, 0.2-7.8). The prognostic ability of the ESC model remained significant in the subgroup of patients at high-risk according to the sPESI model (OR 1.95, 95% CI, 1.41 to 2.71, P < .001). Conclusions: Both the sPESI and the ESC model successfully predict 30-day mortality after acute symptomatic PE, but exclusion of an adverse early outcome does not appear to require routine imaging procedures or laboratory biomarker testing.

Original languageEnglish
Pages (from-to)916-922
Number of pages7
JournalCHEST
Volume141
Issue number4
DOIs
StatePublished - Apr 2012

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