TY - JOUR
T1 - A Stereolithography-Based 3D Printed Hybrid Scaffold for In Situ Cartilage Defect Repair
AU - Aisenbrey, Elizabeth A.
AU - Tomaschke, Andrew
AU - Kleinjan, Eric
AU - Muralidharan, Archish
AU - Pascual-Garrido, Cecilia
AU - McLeod, Robert R.
AU - Ferguson, Virginia L.
AU - Bryant, Stephanie J.
N1 - Funding Information:
Research reported in this publication was supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health under Award Number 1R01AR069060. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. The authors acknowledge the Department of Education’s Graduate Assistantship in Areas of National Need to EAA. The authors acknowledge Karin Payne and Francisco Fontan for their assistance in creating the osteochondral plugs and Stanley Chu and Margaret Schneider for their assistance in isolating bovine chondrocytes.
Funding Information:
Research reported in this publication was supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health under Award Number 1R01AR069060. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. The authors acknowledge the Department of Education's Graduate Assistantship in Areas of National Need to EAA. The authors acknowledge Karin Payne and Francisco Fontan for their assistance in creating the osteochondral plugs and Stanley Chu and Margaret Schneider for their assistance in isolating bovine chondrocytes.
Publisher Copyright:
© 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
PY - 2018/2
Y1 - 2018/2
N2 - Damage to articular cartilage can over time cause degeneration to the tissue surrounding the injury. To address this problem, scaffolds that prevent degeneration and promote neotissue growth are needed. A new hybrid scaffold that combines a stereolithography-based 3D printed support structure with an injectable and photopolymerizable hydrogel for delivering cells to treat focal chondral defects is introduced. In this proof of concept study, the ability to a) infill the support structure with an injectable hydrogel precursor solution, b) incorporate cartilage cells during infilling using a degradable hydrogel that promotes neotissue deposition, and c) minimize damage to the surrounding cartilage when the hybrid scaffold is placed in situ in a focal chondral defect in an osteochondral plug that is cultured under mechanical loading is demonstrated. With the ability to independently control the properties of the structure and the injectable hydrogel, this hybrid scaffold approach holds promise for treating chondral defects.
AB - Damage to articular cartilage can over time cause degeneration to the tissue surrounding the injury. To address this problem, scaffolds that prevent degeneration and promote neotissue growth are needed. A new hybrid scaffold that combines a stereolithography-based 3D printed support structure with an injectable and photopolymerizable hydrogel for delivering cells to treat focal chondral defects is introduced. In this proof of concept study, the ability to a) infill the support structure with an injectable hydrogel precursor solution, b) incorporate cartilage cells during infilling using a degradable hydrogel that promotes neotissue deposition, and c) minimize damage to the surrounding cartilage when the hybrid scaffold is placed in situ in a focal chondral defect in an osteochondral plug that is cultured under mechanical loading is demonstrated. With the ability to independently control the properties of the structure and the injectable hydrogel, this hybrid scaffold approach holds promise for treating chondral defects.
KW - 3D printing
KW - cartilage
KW - focal defect
KW - hydrogel
KW - stereolithography
UR - http://www.scopus.com/inward/record.url?scp=85041947343&partnerID=8YFLogxK
U2 - 10.1002/mabi.201700267
DO - 10.1002/mabi.201700267
M3 - Article
C2 - 29266791
AN - SCOPUS:85041947343
SN - 1616-5187
VL - 18
JO - Macromolecular Bioscience
JF - Macromolecular Bioscience
IS - 2
M1 - 1700267
ER -