A steganalysis-based approach to comprehensive identification and characterization of functional elements

Guandong Wang; Weixiong Zhang

doi:10.1186/gb-2006-7-6-r49

A steganalysis-based approach to comprehensive identification and characterization of functional elements

Guandong Wang, Weixiong Zhang

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Abstract

The comprehensive identification of cis-regulatory elements on a genome scale is a challenging problem. We develop a novel, steganalysis-based approach for genome-wide motif finding, called WordSpy, by viewing regulatory regions as a stegoscript with cis-elements embedded in 'background' sequences. We apply WordSpy to the promoters of cell-cycle-related genes of Saccharomyces cerevisiae and Arabidopsis thaliana, identifying all known cell-cycle motifs with high ranking. WordSpy can discover a complete set of cis-elements and facilitate the systematic study of regulatory networks.

Original language	English
Article number	R49
Journal	Genome biology
Volume	7
Issue number	6
DOIs	https://doi.org/10.1186/gb-2006-7-6-r49
State	Published - Jun 20 2006

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A steganalysis-based approach to comprehensive identification and characterization of functional elements

Abstract

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