A software app for radiotherapy with in-situ dose-painting using high Z nanoparticles

M. Jermoumi, A. Yucel, Y. Hao, G. Cifter, E. Sajo, W. Ngwa

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

The purpose of this work is to develop a user friendly and free-to-download application software that can be employed for modeling Radiotherapy with In-situ Dosepainting (RAID) using high-Z nanoparticles (HZNPs). The RAID APP is software program written in Matlab (Mathworks, Natick, MA, USA) based on deterministic code developed to simulate the space-time intra-tumor HZNPs biodistribution within the tumor, and the corresponding dose enhancement in response to low dose rate (LDR) brachytherapy of I-125, Pd-102, Cs-131 and kilovoltage x-rays such as 50 keV and 100 keV. Through the graphical user interface (GUI) of the RAID APP, the user will be directed to different features to compute various parameters related to the dose enhancement and the biodistribution of NPs within high risk tumor sub-volumes. The software was developed as a tool for research purposes with potential for subsequent development to guide dose-painting treatment planning using radiosensitizers such as gold (Au) and platinum (Pt).

Original languageEnglish
Title of host publicationWorld Congress on Medical Physics and Biomedical Engineering, 2015
EditorsDavid A. Jaffray
PublisherSpringer Verlag
Pages618-621
Number of pages4
ISBN (Print)9783319193878
DOIs
StatePublished - 2015
EventWorld Congress on Medical Physics and Biomedical Engineering, 2015 - Toronto, Canada
Duration: Jun 7 2015Jun 12 2015

Publication series

NameIFMBE Proceedings
Volume51
ISSN (Print)1680-0737

Conference

ConferenceWorld Congress on Medical Physics and Biomedical Engineering, 2015
Country/TerritoryCanada
CityToronto
Period06/7/1506/12/15

Keywords

  • Dose enhancement
  • Dose painting
  • High atomic number nanoparticles

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