A single misstep in cardiac development explains the co-occurrence of tetralogy of fallot and complete atrioventricular septal defect in down syndrome

Hoang H. Nguyen; Patrick Y. Jay

doi:10.1016/j.jpeds.2014.02.065

A single misstep in cardiac development explains the co-occurrence of tetralogy of fallot and complete atrioventricular septal defect in down syndrome

Hoang H. Nguyen, Patrick Y. Jay

Division of Cardiology

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Tetralogy of Fallot and a complete atrioventricular septal defect are thought to arise by distinct mechanisms, yet their co-occurrence is a recognized association. Analysis of the prevalence of co-occurrence in Down syndrome suggests a common developmental basis. Trisomy 21 may perturb cardiac progenitor cells before they enter the heart tube.

Original language	English
Pages (from-to)	194-196
Number of pages	3
Journal	Journal of Pediatrics
Volume	165
Issue number	1
DOIs	https://doi.org/10.1016/j.jpeds.2014.02.065
State	Published - Jul 2014

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abstract = "Tetralogy of Fallot and a complete atrioventricular septal defect are thought to arise by distinct mechanisms, yet their co-occurrence is a recognized association. Analysis of the prevalence of co-occurrence in Down syndrome suggests a common developmental basis. Trisomy 21 may perturb cardiac progenitor cells before they enter the heart tube.",

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AB - Tetralogy of Fallot and a complete atrioventricular septal defect are thought to arise by distinct mechanisms, yet their co-occurrence is a recognized association. Analysis of the prevalence of co-occurrence in Down syndrome suggests a common developmental basis. Trisomy 21 may perturb cardiac progenitor cells before they enter the heart tube.

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A single misstep in cardiac development explains the co-occurrence of tetralogy of fallot and complete atrioventricular septal defect in down syndrome

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