A single intranasal dose of chimpanzee adenovirus-vectored vaccine protects against SARS-CoV-2 infection in rhesus macaques

Ahmed O. Hassan, Friederike Feldmann, Haiyan Zhao, David T. Curiel, Atsushi Okumura, Tsing Lee Tang-Huau, James Brett Case, Kimberly Meade-White, Julie Callison, Rita E. Chen, Jamie Lovaglio, Patrick W. Hanley, Dana P. Scott, Daved H. Fremont, Heinz Feldmann, Michael S. Diamond

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

The deployment of a vaccine that limits transmission and disease likely will be required to end the coronavirus disease 2019 (COVID-19) pandemic. We recently described the protective activity of an intranasally administered chimpanzee adenovirus-vectored vaccine encoding a pre-fusion stabilized spike (S) protein (ChAd-SARS-CoV-2-S [chimpanzee adenovirus-severe acute respiratory syndrome-coronavirus-2-S]) in the upper and lower respiratory tracts of mice expressing the human angiotensin-converting enzyme 2 (ACE2) receptor. Here, we show the immunogenicity and protective efficacy of this vaccine in non-human primates. Rhesus macaques were immunized with ChAd-Control or ChAd-SARS-CoV-2-S and challenged 1 month later by combined intranasal and intrabronchial routes with SARS-CoV-2. A single intranasal dose of ChAd-SARS-CoV-2-S induces neutralizing antibodies and T cell responses and limits or prevents infection in the upper and lower respiratory tracts after SARS-CoV-2 challenge. As ChAd-SARS-CoV-2-S confers protection in non-human primates, it is a promising candidate for limiting SARS-CoV-2 infection and transmission in humans.

Original languageEnglish
Article number100230
JournalCell Reports Medicine
Volume2
Issue number4
DOIs
StatePublished - Apr 20 2021

Keywords

  • SARS-CoV-2
  • adenoviral vector
  • immunity
  • immunogenicity
  • mucosal
  • non-human primates
  • protection
  • vaccine

Fingerprint

Dive into the research topics of 'A single intranasal dose of chimpanzee adenovirus-vectored vaccine protects against SARS-CoV-2 infection in rhesus macaques'. Together they form a unique fingerprint.

Cite this