A single-cell guide to retinal development: Cell fate decisions of multipotent retinal progenitors in scRNA-seq

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Abstract

Recent advances in high throughput single-cell RNA sequencing (scRNA-seq) technology have enabled the simultaneous transcriptomic profiling of thousands of individual cells in a single experiment. To investigate the intrinsic process of retinal development, researchers have leveraged this technology to quantify gene expression in retinal cells across development, in multiple species, and from numerous important models of human disease. In this review, we summarize recent applications of scRNA-seq and discuss how these datasets have complemented and advanced our understanding of retinal progenitor cell competence, cell fate specification, and differentiation. Finally, we also highlight the outstanding questions in the field that advances in single-cell data generation and analysis will soon be able to answer.

Original languageEnglish
Pages (from-to)41-58
Number of pages18
JournalDevelopmental Biology
Volume478
DOIs
StatePublished - Oct 2021

Keywords

  • Cell fate specification
  • Competence
  • Neurogenesis
  • Retinal development
  • Retinal progenitor cells
  • Review
  • Single-cell
  • Single-cell rna-sequencing
  • scRNA-seq

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