A single aquaporin gene encodes a water/glycerol/urea facilitator in Toxoplasma gondii with similarity to plant tonoplast intrinsic proteins

Slavica Pavlovic-Djuranovic, Joachim E. Schultz, Eric Beitz

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

We describe a single aquaporin gene in Toxoplasma gondii which, surprisingly, has only 28% sequence similarity to the aquaglyceroporin of another apicomplexan parasite, Plasmodium falciparum. Sequence comparisons showed 47% similarity to water-specific plant aquaporins and the conservation of typical pore-forming residues. We established that the Toxoplasma aquaporin protein is a bifunctional membrane pore with intermediate water and high glycerol permeability. Furthermore, we identified hydroxyurea, an antineoplastic agent with inhibitory effects on parasite proliferation, as a permeant of this channel.

Original languageEnglish
Pages (from-to)500-504
Number of pages5
JournalFEBS Letters
Volume555
Issue number3
DOIs
StatePublished - Dec 18 2003

Keywords

  • Aquaglyceroporin
  • Glycerol
  • Hydroxyurea
  • Plasmodium
  • Toxoplasma
  • Water

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