A short course of FK506 can induce limited donor-specific graft acceptance

Takashi Hirai, Thomas K. Waddell, Kleber N. DeCampos, Christopher G. Compeau, Hiromi Wada, Shigeki Hitomi, G. Alexander Patterson, Arthur S. Slutsky

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4 Scopus citations

Abstract

To examine the hypothesis that a short course of FK506 would induce permanent graft acceptance after lung transplantation, left lung allotransplantation was performed in 14 mongrel dogs. In group 1 (control; n = 3), no immunosuppressive agent was given. In group 2 (n = 7), FK506 (1.2 mg/kg intramuscularly) was given on posttransplantation days 0, 1, and 2. In group 3 (n = 4), FK506 was given at the same dose on posttransplantation days 0, 1, and 2 as well as on days 29 and 30. Allograft function was evaluated by temporarily occluding the right pulmonary artery. A mixed lymphocyte reaction study was performed preoperatively and monthly thereafter. Control lungs were all rejected within 8 days. Group 2 dogs showed improved survival, with a median survival of 49.5 days. One dog in group 2 lived more than 400 days after transplantation. The mixed lymphocyte reaction data suggests that some donor-specific unresponsiveness occurs, which lasts for only a limited time. Supplemental doses of FK506 did not significantly improve survival (median, 74 days). The whole blood level of FK506 was 17.7 ± 3.98 ng/mL on day 15; however, on day 29 the FK506 level was almost undetectable. We conclude that a 3-day course of 1.2 mg/kg of FK506 can induce donorspecific graft acceptance, but this acceptance is not permanent.

Original languageEnglish
Pages (from-to)496-501
Number of pages6
JournalThe Annals of thoracic surgery
Volume58
Issue number2
DOIs
StatePublished - Aug 1994
Externally publishedYes

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    Hirai, T., Waddell, T. K., DeCampos, K. N., Compeau, C. G., Wada, H., Hitomi, S., Patterson, G. A., & Slutsky, A. S. (1994). A short course of FK506 can induce limited donor-specific graft acceptance. The Annals of thoracic surgery, 58(2), 496-501. https://doi.org/10.1016/0003-4975(94)92238-1