A sequential electrochemical oxidation - Olefin metathesis strategy for the construction of bicyclic lactam based peptidomimetics

Laura M. Beal, Kevin D. Moeller

Research output: Contribution to journalArticlepeer-review

37 Scopus citations

Abstract

A sequential electrochemical amide oxidation - ring closing olefin metathesis sequence has been used to overcome problems associated with the synthesis of seven-membered ring lactam containing bicyclic peptidomimetics. The synthesis of several previously unavailable bicyelic lactam building blocks for constructing constrained thyroliberin analogs is described.

Original languageEnglish
Pages (from-to)4639-4642
Number of pages4
JournalTetrahedron Letters
Volume39
Issue number26
DOIs
StatePublished - Jun 25 1998

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