A sequence-level map of chromosomal breakpoints in the MCF-7 breast cancer cell line yields insights into the evolution of a cancer genome

Keyphrases

• Breast Cancer Cell Lines 100%
• Cancer Genome 100%
• Sequence-level 100%
• MCF-7 100%
• Low-copy Repeats 100%
• Chromosome Breakage 100%
• SULF2 100%
• Line Yield 100%
• DNA Double-strand Breaks 66%
• Fusion Product 66%
• Knockdown 33%
• Cell Growth 33%
• Protein Complex 33%
• RNA Transcripts 33%
• Angiogenesis 33%
• Array Comparative Genomic Hybridization (aCGH) 33%
• RAD51 33%
• BRIP1 33%
• Improved Survival 33%
• Massively Parallel Sequencing 33%
• Non-homologous End Joining 33%
• Coding Exons 33%
• Gene Coding 33%
• Closely Spaced 33%
• Anchorage-independent Growth 33%
• Chromosomal Aberrations 33%
• DNA Break Repair 33%
• Predicted Genes 33%
• Template Switching 33%
• BACH1 33%
• Breakpoint Junction 33%
• Rearrangement Events 33%
• Chimeric RNA 33%
• Gene Truncation 33%
• ARFGEF2 33%
• ATXN7 33%

Biochemistry, Genetics and Molecular Biology

• Cancer Cell 100%
• Low Copy Repeats 100%
• Double-Strand DNA Break 66%
• Cell Growth 33%
• Angiogenesis 33%
• Exon 33%
• DNA Template 33%
• Protein Complexes 33%
• BRIP1 33%
• RAD51C 33%
• Deep Sequencing 33%
• DNA Flanking Region 33%
• Non-Homologous End Joining 33%
• Array Comparative Genomic Hybridization 33%
• Anchorage Independent Growth 33%
• Chromosomal Aberration 33%
• Chromosome Breakage 33%
• BACH1 33%
• Messenger RNA 33%