Detection of atherosclerosis in its early stages with MRI could lead to more effective treatment of the disease. However, the changes that occur in the vessels of animals given a high cholesterol diet to induce atherosclerosis are not visually apparent with conventional MRI techniques. This paper describes a semi-automated algorithm designed to quantify enhancement of the aortic wall after administration of targeted and non-targeted contrast agents in rabbits given a high cholesterol diet. The performance of the program was evaluated on multiple slices taken from eight rabbits. No lumenal narrowing or overall non-specific contrast enhancement was detected in cholesterol-fed animals. Enhancement after administration of a nanoparticle contrast agent specifically targeted to molecules associated with the initial development of atherosclerosis was higher in the cholesterol fed rabbits, providing an early indicator of disease.
|Number of pages||4|
|Journal||Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings|
|State||Published - Dec 1 2003|
|Event||A New Beginning for Human Health: Proceedings of the 25th Annual International Conference of the IEEE Engineering in Medicine and Biology Society - Cancun, Mexico|
Duration: Sep 17 2003 → Sep 21 2003