@article{93738446c5874e5f894bd18d4897ec19,
title = "A Secreted Viral Nonstructural Protein Determines Intestinal Norovirus Pathogenesis",
abstract = "Norovirus is an enteric virus that infects intestinal epithelial tuft cells in mice. Lee et al. discover that murine norovirus NS1 is an unconventionally secreted protein that overcomes IFN-λ-mediated norovirus control and is critical for intestinal infection in mice. Additionally, vaccination with NS1 alone confers protection, suggesting potential vaccine strategies.",
keywords = "IFN-λ, NS1, norovirus, secretion, vaccine",
author = "Sanghyun Lee and Hejun Liu and Wilen, {Craig B.} and Sychev, {Zoi E.} and Chandni Desai and Hykes, {Barry L.} and Orchard, {Robert C.} and McCune, {Broc T.} and Kim, {Ki Wook} and Nice, {Timothy J.} and Handley, {Scott A.} and Baldridge, {Megan T.} and Amarasinghe, {Gaya K.} and Virgin, {Herbert W.}",
note = "Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",
year = "2019",
month = jun,
day = "12",
doi = "10.1016/j.chom.2019.04.005",
language = "English",
volume = "25",
pages = "845--857.e5",
journal = "Cell Host and Microbe",
issn = "1931-3128",
number = "6",
}