A rotating holeboard procedure for testing drug effects on spatial learning and memory in mice

Gayle Brosnan-Watters, David F. Wozniak

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

A procedure is described heroin for evaluating drug effects on acquisition and retention of a spatial learning task in mice. The rotating holeboard apparatus is a rectangular open field containing four open holes arranged in either a four-corner or a row configuration. A mouse is trained to poke its head into a hole and retrieve a food reward from a 'baited' hole which contains a reward on every trial. A massed trials protocol is used where mice are required to learn a reference (trial-independent) memory task in a single session. A retention test is administered 24 h after acquisition. Prominent distal cues are present in the testing room and reliance on proximal visual, olfactory, or tactile cues for locating the baited hole is precluded by rotating the maze on each trial.

Original languageEnglish
Pages (from-to)331-338
Number of pages8
JournalBrain Research Protocols
Volume1
Issue number4
DOIs
StatePublished - Oct 1 1997

Keywords

  • Holeboard, reference memory
  • Mice
  • Spatial learning and memory
  • Trial- independent memory

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