A revised nomenclature for the human and rodent α-tubulin gene family

Varsha K. Khodiyar, Lois J. Maltais, Katherine M.B. Sneddon, Jennifer R. Smith, Mary Shimoyama, Fernando Cabral, Charles Dumontet, Susan K. Dutcher, Robert J. Harvey, Laurence Lafanechère, John M. Murray, Eva Nogales, David Piquemal, Fabio Stanchi, Sue Povey, Ruth C. Lovering

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Abstract

An essential component of microtubules, α-tubulin is also a multigene family in many species. An orthology-based nomenclature for this gene family has previously been difficult to assign due to incomplete genome builds and the high degree of sequence similarity between members of this family. Using the current genome builds, sequence analysis of human, mouse, and rat α-tubulin genes has enabled an updated nomenclature to be generated. This revised nomenclature provides a unified language for the discussion of these genes in mammalian species; it has been approved by the gene nomenclature committees of the three species and is supported by researchers in the field.

Original languageEnglish
Pages (from-to)285-289
Number of pages5
JournalGenomics
Volume90
Issue number2
DOIs
StatePublished - Aug 2007

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    Khodiyar, V. K., Maltais, L. J., Sneddon, K. M. B., Smith, J. R., Shimoyama, M., Cabral, F., Dumontet, C., Dutcher, S. K., Harvey, R. J., Lafanechère, L., Murray, J. M., Nogales, E., Piquemal, D., Stanchi, F., Povey, S., & Lovering, R. C. (2007). A revised nomenclature for the human and rodent α-tubulin gene family. Genomics, 90(2), 285-289. https://doi.org/10.1016/j.ygeno.2007.04.008