A review on qualifications and cost effectiveness of induced pluripotent stem cells (IPSCs)-induced cardiomyocytes in drug screening tests

Golrokh Malihi, Vahid Nikoui, Elliot L. Elson

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations

Abstract

Human induced pluripotent stem cells (hIPSCs) have initiated a higher degree of successes in disease modelling, preclinical evaluation of drug therapy and pharmaco-toxicological testing. Since the discovery of iPSCs in 2006, many advanced techniques have been introduced to differentiate iPSCs to cardiomyocytes, which have been progressively improved. The disease models from iPSC-induced cardiomyocytes (iPSC-CM) have been successfully helping to study a variety of cardiac diseases such as long QT syndrome, drug-induced long QT, different cardiomyopathies related to mutations in mitochondria or desmosomal proteins and other rare genetic diseases. IPSC-CMs have also been used to screen the role of chemicals in cardiovascular drug discovery and individualisation of drug dosages. In this review, the quality of current procedures for characterisation and maturation of iPSC-CM lines will be discussed. Also, we will focus on time efficiency and cost of standard differentiation methods after reprogramming.

Original languageEnglish
Pages (from-to)131-142
Number of pages12
JournalArchives of Physiology and Biochemistry
Volume129
Issue number1
DOIs
StatePublished - 2023

Keywords

  • cost effectiveness
  • drug screening tests
  • iPSC-CMs
  • maturation

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