A review of lipidomic technologies applicable to sphingolipidomics and their relevant applications

Xianlin Han, Xuntian Jiang

Research output: Contribution to journalReview article

42 Scopus citations

Abstract

Sphingolipidomics, a branch of lipidomics, focuses on the large-scale study of the cellular sphingolipidomes. In the current review, two main approaches for the analysis of cellular sphingolipidomes (i.e. LC-MS-or LC-MS/MS-based approach and shotgun lipidomics-based approach) are briefly discussed. Their advantages, some considerations of these methods, and recent applications of these approaches are summarized. It is the authors' sincere hope that this review article will add to the readers understanding of the advantages and limitations of each developed method for the analysis of a cellular sphingolipidome.

Original languageEnglish
Pages (from-to)39-52
Number of pages14
JournalEuropean Journal of Lipid Science and Technology
Volume111
Issue number1
DOIs
StatePublished - Jan 1 2009

Keywords

  • Intrasource separation
  • Lipidomics
  • Multi-dimensional mass spectrometry
  • Shotgun lipidomics
  • Sphingolipidomics

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