@inbook{bfdd079ba6ee46429cb38e3568af79b7,
title = "A Review of High-Dimensional Mediation Analyses in DNA Methylation Studies",
abstract = "DNA methylation alterations have been widely studied as mediators of environmentally induced disease risks. With new advances in technique, epigenome-wide DNA methylation data (EWAS) have become the new standard for epigenetic studies in human populations. However, to date most epigenetic studies of mediation effects only involve selected (gene-specific) candidate methylation markers. There is an urgent need for appropriate analytical methods for EWAS mediation analysis. In this chapter, we provide an overview of recent advances on high-dimensional mediation analysis, with application to two DNA methylation data.",
keywords = "Epigenetics, False discovery rate, Joint significance test, Mediation analysis, Multiple comparison, Regularization, Variable selection",
author = "Haixiang Zhang and Lifang Hou and Lei Liu",
note = "Publisher Copyright: {\textcopyright} 2022, Springer Science+Business Media, LLC, part of Springer Nature.",
year = "2022",
doi = "10.1007/978-1-0716-1994-0_10",
language = "English",
series = "Methods in Molecular Biology",
publisher = "Humana Press Inc.",
pages = "123--135",
booktitle = "Methods in Molecular Biology",
}