@article{d10827a7afdd42daa7f1578c417b0953,
title = "A review of epidermal growth factor receptor/HER2 inhibitors in the treatment of patients with non-small-cell lung cancer",
abstract = "Advanced non-small-cell lung cancer (NSCLC) remains a major global health problem. Although the reversible epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor erlotinib improves survival in patients with relapsed and recurrent NSCLC, significant limitations exist, including the restriction of clinical efficacy to a small patient subset, poor survival rates, and the development of resistance. Irreversible inhibitors of EGFR and HER2 are novel agents in clinical development that might have the potential to prevent and overcome acquired resistance to first-generation EGFR inhibitors.",
keywords = "BIBW 2992, ErbB, Erlotinib, Gefitinib, HKI-272, Receptor tyrosine kinase",
author = "Ramaswamy Govindan",
note = "Funding Information: This work was supported by Boehringer-Ingelheim Pharmaceuticals, Inc. Writing and editorial assistance was provided by Johnathan Maher, PhD, of BlueSpark Healthcare Communications, and was contracted by Boehringer-Ingelheim Pharmaceuticals, Inc. Dr. Govindan meets the criteria for authorship as recommended by the International Committee of Medical Journal Editors (ICMJE), was fully responsible for all content and editorial decisions, and was involved in all stages of manuscript development. Dr. Govindan received no compensation related to the development of this article. ",
year = "2010",
doi = "10.3816/CLC.2010.n.001",
language = "English",
volume = "11",
pages = "8--12",
journal = "Clinical Lung Cancer",
issn = "1525-7304",
number = "1",
}