14 Scopus citations

Abstract

The ability of animals to replace injured body parts has been a subject of fascination for centuries. The emerging importance of regenerative medicine has reinvigorated investigations of innate tissue regeneration, and the development of powerful genetic tools has fueled discoveries into how tissue regeneration occurs. Here, we present an overview of the armamentarium employed to probe regeneration in vertebrates, highlighting areas where further methodology advancement will deepen mechanistic findings. The emerging importance of regenerative medicine has reinvigorated investigations of innate tissue regeneration, and development of powerful genetic tools has fueled discoveries into how tissue regeneration occurs. Mokalled and Poss present an overview of the armamentarium employed to probe regeneration in vertebrates, highlighting areas where further methodology advancement will deepen mechanistic findings.

Original languageEnglish
Pages (from-to)267-280
Number of pages14
JournalDevelopmental cell
Volume47
Issue number3
DOIs
StatePublished - Nov 5 2018

Keywords

  • gene editing
  • lineage tracing
  • mice
  • model systems
  • salamanders
  • stem cells
  • tissue regeneration
  • zebrafish

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