@article{4f873a2fad5641dba0d084f1f84f2a40,
title = "A Regeneration Toolkit",
abstract = "The ability of animals to replace injured body parts has been a subject of fascination for centuries. The emerging importance of regenerative medicine has reinvigorated investigations of innate tissue regeneration, and the development of powerful genetic tools has fueled discoveries into how tissue regeneration occurs. Here, we present an overview of the armamentarium employed to probe regeneration in vertebrates, highlighting areas where further methodology advancement will deepen mechanistic findings. The emerging importance of regenerative medicine has reinvigorated investigations of innate tissue regeneration, and development of powerful genetic tools has fueled discoveries into how tissue regeneration occurs. Mokalled and Poss present an overview of the armamentarium employed to probe regeneration in vertebrates, highlighting areas where further methodology advancement will deepen mechanistic findings.",
keywords = "gene editing, lineage tracing, mice, model systems, salamanders, stem cells, tissue regeneration, zebrafish",
author = "Mokalled, {Mayssa H.} and Poss, {Kenneth D.}",
note = "Funding Information: We apologize to trainees and principal investigators whose work we omitted or discussed only briefly due to space limitations. We thank J.A. Goldman and V. Cigliola for comments on the manuscript. We acknowledge support from the Washington University School of Medicine, the Missouri Spinal Cord Injury/Disease Research Program, and NIH (T32-HL007101) to M.H.M. and from NIH (R01-GM074057, R01-HL0810674, R01-HL131319, R01-HL136182, and R21-NS096617), Fondation Leducq, and American Heart Association to K.D.P. In memory of Steve Johnson, a rigorous scientist and selfless mentor who pioneered genetic approaches to tissue regeneration. Funding Information: We apologize to trainees and principal investigators whose work we omitted or discussed only briefly due to space limitations. We thank J.A. Goldman and V. Cigliola for comments on the manuscript. We acknowledge support from the Washington University School of Medicine , the Missouri Spinal Cord Injury/Disease Research Program , and NIH ( T32-HL007101 ) to M.H.M. and from NIH ( R01-GM074057 , R01-HL0810674 , R01-HL131319 , R01-HL136182 , and R21-NS096617 ), Fondation Leducq , and American Heart Association to K.D.P. In memory of Steve Johnson, a rigorous scientist and selfless mentor who pioneered genetic approaches to tissue regeneration. Publisher Copyright: {\textcopyright} 2018 Elsevier Inc.",
year = "2018",
month = nov,
day = "5",
doi = "10.1016/j.devcel.2018.10.015",
language = "English",
volume = "47",
pages = "267--280",
journal = "Developmental Cell",
issn = "1534-5807",
number = "3",
}