TY - GEN
T1 - A reconfigurable, additively manufactured vibrotactile stimulation device for chronic pain
AU - Adams, Josh
AU - Demarest, Phillip
AU - Donovan, Kara
AU - Brunner, Peter
AU - Burton, Harold
AU - Haroutounian, Simon
AU - Leuthardt, Eric
AU - Gorlewicz, Jenna
N1 - Publisher Copyright:
© 2023 by ASME.
PY - 2023
Y1 - 2023
N2 - This paper presents an experimental chronic pain rehabilitation therapy utilizing vibration-based stimulation of the hand, wrist and lower arm, which has shown promise in reducing pain ratings in chronic pain patients (n=5) over a six-week treatment period. Based on the clinical need and practical use discoveries of that first trial, this paper outlines the development of a second-generation device that activates specific nerves through vibrotactile stimulation applied to the skin. Several major steps in this process were the iterative design process, physical prototyping, conceptual modeling, and benchtop testing. Furthermore, this next generation device was tested with epilepsy patients undergoing invasive monitoring (stereotactic electroencephalography, sEEG) to collect electrophysiological measurements via implanted electrodes in the brain. Early findings showed differential modulation of delta power in response to 2 Hz median nerve stimulation, but not during 12 Hz median nerve stimulation or 2 Hz ulnar nerve stimulation, hence indicating differential encoding of vibration features depending on frequency and spatial parameters. These patient trials also served to collect feedback for the continued development of the device to improve aspects such as ease of use, patient comfort, and ideal application of the vibration stimulus. Testing and development are ongoing with the enhancement of vibration isolating structures, more comfortable contact points, more durable additively manufactured structures, and embedded force sensors in the device.
AB - This paper presents an experimental chronic pain rehabilitation therapy utilizing vibration-based stimulation of the hand, wrist and lower arm, which has shown promise in reducing pain ratings in chronic pain patients (n=5) over a six-week treatment period. Based on the clinical need and practical use discoveries of that first trial, this paper outlines the development of a second-generation device that activates specific nerves through vibrotactile stimulation applied to the skin. Several major steps in this process were the iterative design process, physical prototyping, conceptual modeling, and benchtop testing. Furthermore, this next generation device was tested with epilepsy patients undergoing invasive monitoring (stereotactic electroencephalography, sEEG) to collect electrophysiological measurements via implanted electrodes in the brain. Early findings showed differential modulation of delta power in response to 2 Hz median nerve stimulation, but not during 12 Hz median nerve stimulation or 2 Hz ulnar nerve stimulation, hence indicating differential encoding of vibration features depending on frequency and spatial parameters. These patient trials also served to collect feedback for the continued development of the device to improve aspects such as ease of use, patient comfort, and ideal application of the vibration stimulus. Testing and development are ongoing with the enhancement of vibration isolating structures, more comfortable contact points, more durable additively manufactured structures, and embedded force sensors in the device.
KW - 3d printing
KW - Additive manufacturing
KW - Brain-computer interface
KW - Chronic pain therapy
KW - Iterative device design
KW - Vibrotactile nerve stimulation
KW - Wearable device
KW - sEEG
UR - http://www.scopus.com/inward/record.url?scp=85165024094&partnerID=8YFLogxK
U2 - 10.1115/DMD2023-9337
DO - 10.1115/DMD2023-9337
M3 - Conference contribution
AN - SCOPUS:85165024094
T3 - Proceedings of the 2023 Design of Medical Devices Conference, DMD 2023
BT - Proceedings of the 2023 Design of Medical Devices Conference, DMD 2023
PB - American Society of Mechanical Engineers
T2 - 2023 Design of Medical Devices Conference, DMD 2023
Y2 - 17 April 2023 through 21 April 2023
ER -