A Real-Time Integrated Backscatter Measurement System for Quantitative Cardiac Tissue Characterization

Lewis J. Thomas, James G. Miller, Samuel A. Wickline, Julio E. Perez, Burton E. Sobel

Research output: Contribution to journalArticlepeer-review

40 Scopus citations


To quantify integrated backscatter of ultrasound for realtime tissue characterization of myocardium in vivo an analog system that is used in conjunction with a two-dimensional/M-mode echocar-diographic imager was developed and evaluated. The system measures the energy contained in a portion of the received rf signal from a selected myocardial segment with a CdS acoustoelectric detector. A standard substitution technique is used to calibrate the system relative to a stainless stEEI reflector. Integrated backscatter is sampled at 5 ms intervals, its time-variation recorded and simultaneously integrated to yield the time-averaged integrated backscatter. Both time-varying and time-averaged integrated backscatter are displayed in real-time. Timeaveraged integrated backscatter in five dogs was -54 +-2.4 dB (SD). Cyclic variations during the cardiac cycle ranged from 5-10 dB. Both the time-averaged and time-varying features of integrated backscatter are consistent with values obtained with earlier measurement systems that required off-line analysis of data. The real-time data acquisition system developed should facilitated clinical tissue characterization with ultrasonic backscatter.

Original languageEnglish
Pages (from-to)27-32
Number of pages6
JournalIEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
Issue number1
StatePublished - Jan 1986


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