A rational approach to unilateral neck rt for head and neck cancers in the era of immunotherapy

Re I. Chin; Joshua P. Schiff; Randall J. Brenneman; Hiram A. Gay; Wade L. Thorstad; Alexander J. Lin

doi:10.3390/cancers13215269

A rational approach to unilateral neck rt for head and neck cancers in the era of immunotherapy

Re I. Chin, Joshua P. Schiff, Randall J. Brenneman, Hiram A. Gay, Wade L. Thorstad, Alexander J. Lin

Research output: Contribution to journal › Review article › peer-review

Abstract

Radiotherapy plays an important role in the definitive and adjuvant treatment of head and neck squamous cell carcinoma (HNSCC). However, standard courses of radiation therapy may contribute to the depletion of circulating lymphocytes and potentially attenuate optimal tumor antigen presentation that may be detrimental to the efficacy of novel immunotherapeutic agents. This review explores the advantages of restricting radiation to the primary tumor/tumor bed and ipsilateral elective neck as it pertains to the evolving field of immunotherapy.

Original language	English
Article number	5269
Journal	Cancers
Volume	13
Issue number	21
DOIs	https://doi.org/10.3390/cancers13215269
State	Published - Nov 1 2021

Keywords

Head and neck cancer
Immunotherapy
Radiation therapy
Unilateral neck RT

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10.3390/cancers13215269

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title = "A rational approach to unilateral neck rt for head and neck cancers in the era of immunotherapy",

abstract = "Radiotherapy plays an important role in the definitive and adjuvant treatment of head and neck squamous cell carcinoma (HNSCC). However, standard courses of radiation therapy may contribute to the depletion of circulating lymphocytes and potentially attenuate optimal tumor antigen presentation that may be detrimental to the efficacy of novel immunotherapeutic agents. This review explores the advantages of restricting radiation to the primary tumor/tumor bed and ipsilateral elective neck as it pertains to the evolving field of immunotherapy.",

keywords = "Head and neck cancer, Immunotherapy, Radiation therapy, Unilateral neck RT",

author = "Chin, {Re I.} and Schiff, {Joshua P.} and Brenneman, {Randall J.} and Gay, {Hiram A.} and Thorstad, {Wade L.} and Lin, {Alexander J.}",

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T1 - A rational approach to unilateral neck rt for head and neck cancers in the era of immunotherapy

AU - Chin, Re I.

AU - Schiff, Joshua P.

AU - Brenneman, Randall J.

AU - Gay, Hiram A.

AU - Thorstad, Wade L.

AU - Lin, Alexander J.

PY - 2021/11/1

Y1 - 2021/11/1

N2 - Radiotherapy plays an important role in the definitive and adjuvant treatment of head and neck squamous cell carcinoma (HNSCC). However, standard courses of radiation therapy may contribute to the depletion of circulating lymphocytes and potentially attenuate optimal tumor antigen presentation that may be detrimental to the efficacy of novel immunotherapeutic agents. This review explores the advantages of restricting radiation to the primary tumor/tumor bed and ipsilateral elective neck as it pertains to the evolving field of immunotherapy.

AB - Radiotherapy plays an important role in the definitive and adjuvant treatment of head and neck squamous cell carcinoma (HNSCC). However, standard courses of radiation therapy may contribute to the depletion of circulating lymphocytes and potentially attenuate optimal tumor antigen presentation that may be detrimental to the efficacy of novel immunotherapeutic agents. This review explores the advantages of restricting radiation to the primary tumor/tumor bed and ipsilateral elective neck as it pertains to the evolving field of immunotherapy.

KW - Head and neck cancer

KW - Immunotherapy

KW - Radiation therapy

KW - Unilateral neck RT

UR - http://www.scopus.com/inward/record.url?scp=85117725435&partnerID=8YFLogxK

U2 - 10.3390/cancers13215269

DO - 10.3390/cancers13215269

M3 - Review article

C2 - 34771432

AN - SCOPUS:85117725435

SN - 2072-6694

VL - 13

JO - Cancers

JF - Cancers

IS - 21

M1 - 5269

ER -

A rational approach to unilateral neck rt for head and neck cancers in the era of immunotherapy

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Keywords

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