A rational approach to unilateral neck rt for head and neck cancers in the era of immunotherapy

Research output: Contribution to journalReview articlepeer-review

Abstract

Radiotherapy plays an important role in the definitive and adjuvant treatment of head and neck squamous cell carcinoma (HNSCC). However, standard courses of radiation therapy may contribute to the depletion of circulating lymphocytes and potentially attenuate optimal tumor antigen presentation that may be detrimental to the efficacy of novel immunotherapeutic agents. This review explores the advantages of restricting radiation to the primary tumor/tumor bed and ipsilateral elective neck as it pertains to the evolving field of immunotherapy.

Original languageEnglish
Article number5269
JournalCancers
Volume13
Issue number21
DOIs
StatePublished - Nov 1 2021

Keywords

  • Head and neck cancer
  • Immunotherapy
  • Radiation therapy
  • Unilateral neck RT

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