A rapid assay for the detection of circulating D-dimer is associated with clinical outcomes among critically ill patients

Marin H. Kollef, Paul R. Eisenberg, William Shannon

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54 Scopus citations

Abstract

Objective: To determine whether the results of a rapid, semiquantitative assay for the detection of circulating D-dimer in whole blood (SRDD assay) are associated with the occurrence of clinical outcomes among critically ill patients. Design: Prospective, blinded, single-center study. Setting: Medical intensive care unit (ICU) of Barnes-Jewish Hospital, St. Louis, MO, a university-affiliated teaching hospital. Patients: Three hundred twenty- three adult patients admitted to a medical ICU. Interventions: Collection of blood samples within 24 hrs of ICU admission. Measurements and Main Results: The main outcome measures evaluated included vascular thrombosis, hospital mortality, and the development of multiorgan dysfunction. Fifty (15.5%) patients were found to have increased concentrations of D-dimer as detected by the SRDD assay within 24 hrs of ICU admission. The concentrations of plasma D-dimer simultaneously measured by an enzyme immunoassay based on the same antibody were significantly greater among patients with a positive SRDD assay compared with patients with a negative SRDD assay (1214 ± 483 vs. 405 ± 407 ng/mL; p < .001). The hospital mortality rate was significantly greater among SRDD-positive patients compared with SRDD-negative patients (32.0% vs. 15.0%; p = .004). SRDD-positive patients also had significantly greater frequencies of acquired multiorgan dysfunction (48.0% vs. 17.6%; p < .001), severe sepsis or septic shock (56.0% vs. 20.9%; p < .001), and vascular thrombosis (14.0% vs. 4.0%; p = .005) compared with SRDD-negative patients. Multiple logistic regression analysis identified the presence of increased concentrations of D-dimer, detected by a positive SRDD assay, as being independently associated with vascular thrombosis (adjusted odds ratio 5.06; 95% confidence interval 2.96 to 8.65; p = .003) and the development of multiorgan dysfunction (adjusted odds ratio 1.51; 95% confidence interval 1.28 to 1.78; p = .012). Conclusions: Our preliminary investigation suggests that the results from a rapid whole blood assay for the semiquantitative detection of circulating D-dimer are associated with clinical outcomes among patients admitted to a medical ICU. In addition, the usa of D-dimer to identify the presence of active intravascular thrombosis may identify patients likely to benefit from antithrombotic therapies in the ICU setting.

Original languageEnglish
Pages (from-to)1054-1060
Number of pages7
JournalCritical care medicine
Volume26
Issue number6
DOIs
StatePublished - 1998

Keywords

  • Coagulation
  • D-dimer
  • Enzyme immunoassay
  • Intensive care
  • Mortality
  • Organ system failure
  • Prognostication
  • Thrombosis

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