A randomized trial of subcutaneous allergy immunotherapy in inner-city children with asthma less than 4 years of age

Gabriele de Vos, Shankar Viswanathan, Yikania Pichardo, Ramin Nazari, Yurydia Jorge, Zhen Ren, Denise Serebrisky, David Rosenstreich, Andrew Wiznia

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Background: Allergic sensitization to environmental allergens in the first years of life is a strong predictor of asthma morbidity in children. Allergy immunotherapy can improve asthma and allergy outcomes, but its efficacy in inner-city, atopic children of less than 4 years of age with recurrent wheezing has not yet been established. Objective: To determine whether subcutaneous allergy immunotherapy improves asthma in a population of US inner-city children when started at less than 4 years of age. Methods: In a randomized controlled, open-label phase I-II single-center trial in the Bronx, New York, 58 children with recurrent wheezing or physician-diagnosed asthma were randomized to receive asthma standard of care treatment with or without a 3-year course of multiple allergen subcutaneous immunotherapy. Results: A total of 23 children in the control group and 27 children in the immunotherapy group began the study. A total of 20 of 27 children commencing immunotherapy completed at least 2 years of immunotherapy. There was no difference in asthma medication and symptom scores between the treatment or control groups over time. Similarly, naso-ocular symptoms and allergy medication use were similar in both groups over time. Nevertheless, asthma-related quality of life improved in the immunotherapy group compared with the control group (P = .03). Conclusion: With the exception of asthma-related quality of life, allergy immunotherapy was ineffective in improving asthma outcomes in this population of inner-city children of less than 4 years of age. These findings suggest that the effects of allergy immunotherapy depend on population-specific factors and highlight the importance of precise predictors of immunotherapy efficacy. Trial Registration: ClinicalTrials.gov Identifier: NCT01028560.

Original languageEnglish
Pages (from-to)367-377.e5
JournalAnnals of Allergy, Asthma and Immunology
Issue number4
StatePublished - Apr 2021


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