A randomized, prospective study comparing laser-assisted hatching and assisted hatching using acidified medium

Susan E. Lanzendorf, Valerie S. Ratts, Kelle H. Moley, Jerald S. Goldstein, Michael H. Dahan, Randall R. Odem

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

Objective: To compare the clinical outcomes of patients whose transferred embryos underwent either laser-assisted hatching or hatching with acidified medium. Design: Randomized, prospective, double-blinded study. Setting: University-based IVF center. Patient(s): Clinical outcomes following IVF were compared in 159 patient cycles who randomly had all transferred embryos undergo laser-assisted hatching (Laser; n = 57) or hatching with acidified medium (Acid; n = 54). Patients whose embryos had zonae thickness <13 μm were not hatched (Thin; n = 8) and patients with ≥4 embryos at the 7- to 8-cell stage or higher on Day 3 were transferred on Day 5 (Day 5; n = 40). Main Outcome Measure(s): Implantation rates, clinical pregnancy rates, ongoing pregnancy rates, multiple pregnancy rates. Result(s): No significant differences were noted in clinical, ongoing, or multiple pregnancy rates between the four groups. The implantation rate for Day 5 transfers was significantly greater than both the Laser and Acid treatment groups. Conclusion: The use of a 1.48-micron infrared diode laser beam provides a safe and rapid method for performing assisted hatching and did not have a negative impact on patient care when compared to outcomes achieved using acidified medium.

Original languageEnglish
Pages (from-to)1450-1457
Number of pages8
JournalFertility and Sterility
Volume87
Issue number6
DOIs
StatePublished - Jun 1 2007

Keywords

  • IVF
  • Laser-assisted hatching
  • acidified medium

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