A Radium-223 microgenerator from cyclotron-produced trace Actinium-227

Diane S. Abou, Juile Pickett, John E. Mattson, Daniel L.J. Thorek

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

The alpha particle emitter Radium-223 dichloride (223RaCl2) has recently been approved for treatment of late-stage bone metastatic prostate cancer. There is considerable interest in studying this new agent outside of the clinical setting, however the supply of 223Ra is limited and expensive. We have engineered a 223Ra microgenerator using traces of 227Ac previously generated from cyclotron-produced 225Ac. Radiochemically pure 223RaCl2 was made, characterized, evaluated in vivo, and the source was recovered in high yield for regeneration of the microgenerator.

Original languageEnglish
Pages (from-to)36-42
Number of pages7
JournalApplied Radiation and Isotopes
Volume119
DOIs
StatePublished - Jan 1 2017
Externally publishedYes

Keywords

  • Ac
  • Microgenerator
  • Purification
  • Ra
  • Th

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