@article{c0e4fc8dfde747fa8b7d92f4d7b63d9e,
title = "A Radium-223 microgenerator from cyclotron-produced trace Actinium-227",
abstract = "The alpha particle emitter Radium-223 dichloride (223RaCl2) has recently been approved for treatment of late-stage bone metastatic prostate cancer. There is considerable interest in studying this new agent outside of the clinical setting, however the supply of 223Ra is limited and expensive. We have engineered a 223Ra microgenerator using traces of 227Ac previously generated from cyclotron-produced 225Ac. Radiochemically pure 223RaCl2 was made, characterized, evaluated in vivo, and the source was recovered in high yield for regeneration of the microgenerator.",
keywords = "Ac, Microgenerator, Purification, Ra, Th",
author = "Abou, {Diane S.} and Juile Pickett and Mattson, {John E.} and Thorek, {Daniel L.J.}",
note = "Funding Information: We would like to thank Dr. Mirzadeh, and the DOE isotope program for supplying the cyclotron-produced 225/227 Ac source. We are grateful to Dr. Granlund (JHU) for his introduction to multichannel analysis. We thank Dr. Soderquist (DOE) and Dr. McDevitt (MSKCC) for their recommendations. This work was supported Steve Wynn Young Investigator Award from the Prostate Cancer Foundation ; the Patrick C. Walsh Fund ; the National Institutes of Health National Cancer Institute R01-CA201035 (DLJT); Prostate Cancer SPORE P50CA058236 (DLJT); the Society of Nuclear Medicine and Molecular Imaging Junior Faculty Fund 120295 (DSA); and NIH - T32AR067708 (JP). Publisher Copyright: {\textcopyright} 2016 The Authors",
year = "2017",
month = jan,
day = "1",
doi = "10.1016/j.apradiso.2016.10.015",
language = "English",
volume = "119",
pages = "36--42",
journal = "Applied Radiation and Isotopes",
issn = "0969-8043",
}