TY - JOUR
T1 - A Query Tool for Investigator Access to the Data and Images of the National Lung Screening Trial
AU - Commean, Paul K.
AU - Rathmell, Joshua M.
AU - Clark, Ken W.
AU - Maffitt, Dave R.
AU - Prior, Fred W.
N1 - Funding Information:
The NLST was a collaborative effort of the National Cancer Institute’s Division of Cancer Prevention, which funded and administered the Lung Screening Study (NLST-LSS), and the American College of Radiology Imaging Network (ACRIN) [], funded by the Division of Cancer Treatment and Diagnosis, which administered the NLST-ACRIN. Westat [] collected and managed the NLST-LSS data, with statistical analysis provided by the Information Management Services (IMS) (Rockville, MD). NLST-LSS contracted blinded university to collect all LSS CT images; chest X-rays were retained by screening sites. ACRIN collected and managed the NLST-ACRIN data and radiology images, with statistical analysis provided by the Brown University (Providence, Rhode Island) ACRIN Biostatistics Center (Brown). Under harmonized protocols, the NLST was conducted through two networks of screening centers: NLST-LSS (10 centers; 34,612 participants) and the NLST-ACRIN (23 centers; 18,840 participants). Screening exams and image collection concluded in 2007 while follow-up data were collected into 2010. Trial results, announced in 2011, indicated that low-dose spiral CT screening reduces lung cancer mortality in persons at high risk for developing lung cancer and is superior to CR screening []. Following the conclusion of NLST, all non-image data (hereafter, “data”) were delivered to IMS and all CT images to blinded university. The CT images have been added to The Cancer Imaging Archive (TCIA) [, ].
Publisher Copyright:
© 2015, Society for Imaging Informatics in Medicine.
PY - 2015/8/26
Y1 - 2015/8/26
N2 - The National Cancer Institute (NCI), in conjunction with blinded university, provides a mechanism to enable public access to the study data, CT radiology images, and pathology images from the National Lung Screening Trial (NLST). Access to the data and images is through the NCI-sponsored, blinded university-hosted The Cancer Imaging Archive (TCIA), a repository of more than 40 study collections of cancer images. Once access to the NLST data has been granted by NCI, a Query Tool within TCIA is used to access the NLST data and images. The Query Tool is a simple-to-use menu-driven database application designed to quickly pose queries and retrieve/save results (from 53,452 NLST participants), download CT images (~20 million available), and view pathology images (~1200 available). NLST study data are contained in 17 Query Tool tables with ~370 variables to query. This paper describes Query Tool design, functionality, and usefulness for researchers, clinicians, and software developers to query data, save query results, and download/view images.
AB - The National Cancer Institute (NCI), in conjunction with blinded university, provides a mechanism to enable public access to the study data, CT radiology images, and pathology images from the National Lung Screening Trial (NLST). Access to the data and images is through the NCI-sponsored, blinded university-hosted The Cancer Imaging Archive (TCIA), a repository of more than 40 study collections of cancer images. Once access to the NLST data has been granted by NCI, a Query Tool within TCIA is used to access the NLST data and images. The Query Tool is a simple-to-use menu-driven database application designed to quickly pose queries and retrieve/save results (from 53,452 NLST participants), download CT images (~20 million available), and view pathology images (~1200 available). NLST study data are contained in 17 Query Tool tables with ~370 variables to query. This paper describes Query Tool design, functionality, and usefulness for researchers, clinicians, and software developers to query data, save query results, and download/view images.
KW - Cancer imaging
KW - Clinical studies data access
KW - Data repository
KW - Database querying
KW - Image archive
KW - NLST
KW - Pathology viewer
KW - Query tool
KW - caMicroscope
UR - http://www.scopus.com/inward/record.url?scp=84937968669&partnerID=8YFLogxK
U2 - 10.1007/s10278-015-9785-5
DO - 10.1007/s10278-015-9785-5
M3 - Article
C2 - 25739345
AN - SCOPUS:84937968669
SN - 0897-1889
VL - 28
SP - 439
EP - 447
JO - Journal of Digital Imaging
JF - Journal of Digital Imaging
IS - 4
ER -