A prototype hybrid intraoperative probe for ovarian cancer detection

John Gamelin; Yi Yang; Nrusingh Biswal; Yueli Chen; Shikui Yan; Xiaoguang Zhang; Mozafareddin Karemeddini; Molly Brewer; Quing Zhu

doi:10.1364/OE.17.007245

A prototype hybrid intraoperative probe for ovarian cancer detection

John Gamelin
, Yi Yang
, Nrusingh Biswal
, Yueli Chen
, Shikui Yan
, Xiaoguang Zhang
, Mozafareddin Karemeddini
, Molly Brewer
, Quing Zhu

Department of Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

A novel prototype intraoperative system combining positron detection and optical coherence tomography (OCT) imaging has been developed for early ovarian cancer detection. The probe employs eight plastic scintillating fiber tips for preferential detection of local positron activity surrounding a central scanning OCT fiber providing volumetric imaging of tissue structure in regions of high radiotracer uptake. Characterization measurements of positron sensitivity, spatial response, and position mapping are presented for Tl²⁰⁴/ Cs¹³⁷ sources as well as 18F-FDG. In conjunction with co-registered frequency domain OCT measurements the results demonstrate the potential for a miniaturized laparoscopic probe offering simultaneous functional localization and structural imaging for improved early cancer detection.

Original language	English
Pages (from-to)	7245-7258
Number of pages	14
Journal	Optics Express
Volume	17
Issue number	9
DOIs	https://doi.org/10.1364/OE.17.007245
State	Published - Apr 27 2009

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abstract = "A novel prototype intraoperative system combining positron detection and optical coherence tomography (OCT) imaging has been developed for early ovarian cancer detection. The probe employs eight plastic scintillating fiber tips for preferential detection of local positron activity surrounding a central scanning OCT fiber providing volumetric imaging of tissue structure in regions of high radiotracer uptake. Characterization measurements of positron sensitivity, spatial response, and position mapping are presented for Tl204/ Cs137 sources as well as 18F-FDG. In conjunction with co-registered frequency domain OCT measurements the results demonstrate the potential for a miniaturized laparoscopic probe offering simultaneous functional localization and structural imaging for improved early cancer detection.",

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AU - Gamelin, John

AU - Yang, Yi

AU - Biswal, Nrusingh

AU - Chen, Yueli

AU - Yan, Shikui

AU - Zhang, Xiaoguang

AU - Karemeddini, Mozafareddin

AU - Brewer, Molly

AU - Zhu, Quing

PY - 2009/4/27

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AB - A novel prototype intraoperative system combining positron detection and optical coherence tomography (OCT) imaging has been developed for early ovarian cancer detection. The probe employs eight plastic scintillating fiber tips for preferential detection of local positron activity surrounding a central scanning OCT fiber providing volumetric imaging of tissue structure in regions of high radiotracer uptake. Characterization measurements of positron sensitivity, spatial response, and position mapping are presented for Tl204/ Cs137 sources as well as 18F-FDG. In conjunction with co-registered frequency domain OCT measurements the results demonstrate the potential for a miniaturized laparoscopic probe offering simultaneous functional localization and structural imaging for improved early cancer detection.

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JO - Optics Express

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A prototype hybrid intraoperative probe for ovarian cancer detection

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