TY - JOUR
T1 - A prototype device for non-invasive continuous monitoring of intracerebral hemorrhage
AU - Korfhagen, Joseph J.
AU - Kandadai, Madhuvanthi A.
AU - Clark, Joseph F.
AU - Adeoye, Opeolu
AU - Shaw, George J.
N1 - Funding Information:
The authors gratefully acknowledge the support of the Point-Of-Care Center for Emergency Neuro Technologies (POCCENT) grant program as funded through NIBIB/NIH . The authors also would like to thank the Department of Emergency Medicine at the University of Cincinnati for equipment funding.
PY - 2013/2/15
Y1 - 2013/2/15
N2 - A prototype for a non-invasive, real-time, monitoring device was developed to detect changes in the brain secondary to disease or injury such as intracerebral hemorrhage (ICH). The eventual goal is a non-invasive, real time sensor that can alert the clinician to alterations in the comatose patient's brain resulting from hemorrhage, seizure or stroke. In this work, a 400MHz electromagnetic (EM) signal was transmitted with an antenna (T), incident on a 'brain gel' in vitro ICH model, and received by a receiving (R) antenna. Changes in the received signal were found to be induced by the presence of blood. The received power (PR) was found to be a linear function of the cross sectional area of blood, as measured normal to the incident wave. In addition, the sensor was able to detect as little as 1mL of blood in this 1000mL in vitro model.
AB - A prototype for a non-invasive, real-time, monitoring device was developed to detect changes in the brain secondary to disease or injury such as intracerebral hemorrhage (ICH). The eventual goal is a non-invasive, real time sensor that can alert the clinician to alterations in the comatose patient's brain resulting from hemorrhage, seizure or stroke. In this work, a 400MHz electromagnetic (EM) signal was transmitted with an antenna (T), incident on a 'brain gel' in vitro ICH model, and received by a receiving (R) antenna. Changes in the received signal were found to be induced by the presence of blood. The received power (PR) was found to be a linear function of the cross sectional area of blood, as measured normal to the incident wave. In addition, the sensor was able to detect as little as 1mL of blood in this 1000mL in vitro model.
KW - Brain monitoring
KW - Hematoma expansion
KW - Intra-cerebral hemorrhage
KW - Microwave tomography
KW - Stroke
UR - http://www.scopus.com/inward/record.url?scp=84872548877&partnerID=8YFLogxK
U2 - 10.1016/j.jneumeth.2012.12.007
DO - 10.1016/j.jneumeth.2012.12.007
M3 - Article
C2 - 23261653
AN - SCOPUS:84872548877
SN - 0165-0270
VL - 213
SP - 132
EP - 137
JO - Journal of Neuroscience Methods
JF - Journal of Neuroscience Methods
IS - 1
ER -