A prospective study on supplemental vitamin E intake and risk of colon cancer in women and men

Kana Wu, Walter C. Willett, June M. Chan, Charles S. Fuchs, Graham A. Colditz, Eric B. Rimm, Edward L. Giovannucci

Research output: Contribution to journalArticlepeer-review

43 Scopus citations

Abstract

We conducted a prospective study on the association between supplemental vitamin E and colon cancer in 87,998 females from the Nurses' Health Study and 47, 344 males from the Health Professionals Follow-up Study. There was some suggestion that men with supplemental vitamin E intake of 300 IU/day or more may be at lower risk for colon cancer when compared with never users [multivariate relative risk (RR), 300-500 IU/day versus never users, 0.73 (95% confidence interval (CI), 0.52-1.03); ≥600 IU/day versus never users = 0.70 (95% CI = 0.38-1.29)], but CIs included 1. In women, there was no evidence for an inverse association between vitamin E supplementation and risk of colon cancer. Our findings do not provide consistent support for an inverse association between supplemental vitamin E and colon cancer risk. Considering the paucity of epidemiological data on this association, further studies of vitamin E and colon cancer are warranted.

Original languageEnglish
Pages (from-to)1298-1304
Number of pages7
JournalCancer Epidemiology Biomarkers and Prevention
Volume11
Issue number11
StatePublished - Nov 1 2002

Fingerprint Dive into the research topics of 'A prospective study on supplemental vitamin E intake and risk of colon cancer in women and men'. Together they form a unique fingerprint.

Cite this