TY - JOUR
T1 - A Prospective Study of Postmenopausal Estrogen Therapy and Coronary Heart Disease
AU - Stampfer, Meir J.
AU - Willett, Walter C.
AU - Colditz, Graham A.
AU - Rosner, Bernard
AU - Speizer, Frank E.
AU - Hennekens, Charles H.
PY - 1985/10/24
Y1 - 1985/10/24
N2 - THE possible role of exogenous estrogens in coronary heart disease has been controversial for decades. The observations that premenopausal women are at lower risk for coronary disease than postmenopausal women and that estrogens favorably influence serum lipid levels1 2 3 led investigators to test estrogen in a trial among men with a prior myocardial infarction.4 However, estrogen therapy was stopped when an excess of coronary disease was observed.4,5 One case–control study in women showed an elevated risk of coronary disease among estrogen users,6,7 but several recent investigations have found an inverse association.8,9 In the United States, postmenopausal hormones are used by 2.
AB - THE possible role of exogenous estrogens in coronary heart disease has been controversial for decades. The observations that premenopausal women are at lower risk for coronary disease than postmenopausal women and that estrogens favorably influence serum lipid levels1 2 3 led investigators to test estrogen in a trial among men with a prior myocardial infarction.4 However, estrogen therapy was stopped when an excess of coronary disease was observed.4,5 One case–control study in women showed an elevated risk of coronary disease among estrogen users,6,7 but several recent investigations have found an inverse association.8,9 In the United States, postmenopausal hormones are used by 2.
UR - http://www.scopus.com/inward/record.url?scp=0022379663&partnerID=8YFLogxK
U2 - 10.1056/NEJM198510243131703
DO - 10.1056/NEJM198510243131703
M3 - Article
C2 - 4047106
AN - SCOPUS:0022379663
SN - 0028-4793
VL - 313
SP - 1044
EP - 1049
JO - New England Journal of Medicine
JF - New England Journal of Medicine
IS - 17
ER -