A Prospective Study of Postmenopausal Estrogen Therapy and Coronary Heart Disease

Meir J. Stampfer, Walter C. Willett, Graham A. Colditz, Bernard Rosner, Frank E. Speizer, Charles H. Hennekens

Research output: Contribution to journalArticle

693 Scopus citations

Abstract

THE possible role of exogenous estrogens in coronary heart disease has been controversial for decades. The observations that premenopausal women are at lower risk for coronary disease than postmenopausal women and that estrogens favorably influence serum lipid levels1 2 3 led investigators to test estrogen in a trial among men with a prior myocardial infarction.4 However, estrogen therapy was stopped when an excess of coronary disease was observed.4,5 One case–control study in women showed an elevated risk of coronary disease among estrogen users,6,7 but several recent investigations have found an inverse association.8,9 In the United States, postmenopausal hormones are used by 2.

Original languageEnglish
Pages (from-to)1044-1049
Number of pages6
JournalNew England Journal of Medicine
Volume313
Issue number17
DOIs
StatePublished - Oct 24 1985
Externally publishedYes

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