A prospective randomized comparison of zygote intrafallopian transfer and in vitro fertilization-embryo transfer for nontubal factor infertility

M. R. Fluker, C. G. Zouves, M. W. Bebbington

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

Objective: To evaluate the efficacy of zygote intrafallopian transfer (ZIFT) versus standard IVF-ET for the treatment of nontubal factor infertility. Design: A prospective randomized trial. Participants: Fifty- nine couples undergoing oocyte retrieval for nontubal infertility in a university hospital-based IVF-ET program. Interventions: A maximum of four cleaving embryos were transferred into the fallopian tube or uterine cavity 48 or 55 hours after oocyte retrieval, respectively. Main Outcome Measures: Rates of implantation, pregnancy, and spontaneous abortion (SAB) were compared. Results: Clinical pregnancies occurred after 26.5% versus 12% of retrievals and 29% versus 14.3% of transfers in IVF-ET versus ZIFT cycles, respectively. Pregnancy, implantation, and SAB rates did not differ between the groups. Conclusions: This prospective randomized trial failed to demonstrate any therapeutic improvement associated with the increased complexity of ZIFT as compared with standard IVF-ET.

Original languageEnglish
Pages (from-to)515-519
Number of pages5
JournalFertility and Sterility
Volume60
Issue number3
DOIs
StatePublished - 1993

Keywords

  • In vitro fertilization
  • embryo transfer
  • meta-analysis
  • tubal transfer
  • zygote intrafallopian transfer

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