TY - JOUR
T1 - A prospective randomized comparison of zygote intrafallopian transfer and in vitro fertilization-embryo transfer for nontubal factor infertility
AU - Fluker, M. R.
AU - Zouves, C. G.
AU - Bebbington, M. W.
PY - 1993
Y1 - 1993
N2 - Objective: To evaluate the efficacy of zygote intrafallopian transfer (ZIFT) versus standard IVF-ET for the treatment of nontubal factor infertility. Design: A prospective randomized trial. Participants: Fifty- nine couples undergoing oocyte retrieval for nontubal infertility in a university hospital-based IVF-ET program. Interventions: A maximum of four cleaving embryos were transferred into the fallopian tube or uterine cavity 48 or 55 hours after oocyte retrieval, respectively. Main Outcome Measures: Rates of implantation, pregnancy, and spontaneous abortion (SAB) were compared. Results: Clinical pregnancies occurred after 26.5% versus 12% of retrievals and 29% versus 14.3% of transfers in IVF-ET versus ZIFT cycles, respectively. Pregnancy, implantation, and SAB rates did not differ between the groups. Conclusions: This prospective randomized trial failed to demonstrate any therapeutic improvement associated with the increased complexity of ZIFT as compared with standard IVF-ET.
AB - Objective: To evaluate the efficacy of zygote intrafallopian transfer (ZIFT) versus standard IVF-ET for the treatment of nontubal factor infertility. Design: A prospective randomized trial. Participants: Fifty- nine couples undergoing oocyte retrieval for nontubal infertility in a university hospital-based IVF-ET program. Interventions: A maximum of four cleaving embryos were transferred into the fallopian tube or uterine cavity 48 or 55 hours after oocyte retrieval, respectively. Main Outcome Measures: Rates of implantation, pregnancy, and spontaneous abortion (SAB) were compared. Results: Clinical pregnancies occurred after 26.5% versus 12% of retrievals and 29% versus 14.3% of transfers in IVF-ET versus ZIFT cycles, respectively. Pregnancy, implantation, and SAB rates did not differ between the groups. Conclusions: This prospective randomized trial failed to demonstrate any therapeutic improvement associated with the increased complexity of ZIFT as compared with standard IVF-ET.
KW - In vitro fertilization
KW - embryo transfer
KW - meta-analysis
KW - tubal transfer
KW - zygote intrafallopian transfer
UR - http://www.scopus.com/inward/record.url?scp=0027303988&partnerID=8YFLogxK
U2 - 10.1016/S0015-0282(16)56170-6
DO - 10.1016/S0015-0282(16)56170-6
M3 - Article
C2 - 8375536
AN - SCOPUS:0027303988
VL - 60
SP - 515
EP - 519
JO - Fertility and Sterility
JF - Fertility and Sterility
SN - 0015-0282
IS - 3
ER -