A prospective observational study examining quality of life in patients with malignant gastric outlet obstruction

Carl Schmidt, Hans Gerdes, William Hawkins, Erica Zucker, Qin Zhou, Elyn Riedel, David Jaques, Arnold Markowitz, Daniel Coit, Mark Schattner

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35 Scopus citations

Abstract

Background: Gastric outlet obstruction (GOO) often complicates advanced malignancy. Palliative options include surgical bypass, endoscopic stent, percutaneous gastrostomy (PEG), or percutaneous jejunostomy (PEJ). Methods: We enrolled 50 patients with GOO secondary to unresectable primary or metastatic cancer in a study examining palliative interventions. Validated instruments assessed quality of life (QOL) at baseline, 1 month, and 3 months following intervention. Results: Median overall survival was 64 days. A shorter hospital stay and trend to lower mortality were observed after stent placement; solid food intake and rates of secondary intervention were comparable. Both stent and surgical bypass were associated with acceptable QOL outcomes. Fifteen patients refused participation at 1 month and 28 died of disease before 3 months, so 10 patients completed all surveys. Conclusions: Although malignant GOO is associated with poor survival, there are reasonable alternatives for palliation. QOL studies are difficult to complete in this population due to severity of illness and short life expectancy.

Original languageEnglish
Pages (from-to)92-99
Number of pages8
JournalAmerican journal of surgery
Volume198
Issue number1
DOIs
StatePublished - Jul 1 2009
Externally publishedYes

Keywords

  • Abdominal neoplasm
  • Endoscopy
  • Gastric outlet obstruction
  • Palliative care
  • Stent

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    Schmidt, C., Gerdes, H., Hawkins, W., Zucker, E., Zhou, Q., Riedel, E., Jaques, D., Markowitz, A., Coit, D., & Schattner, M. (2009). A prospective observational study examining quality of life in patients with malignant gastric outlet obstruction. American journal of surgery, 198(1), 92-99. https://doi.org/10.1016/j.amjsurg.2008.09.030