A preliminary study of cortical S2 serotonin receptors and cognitive performance following stroke

P. L.P. Morris; H. S. Mayberg; K. Bolla; D. F. Wong; R. F. Dannals; S. E. Starkstein; R. G. Robinson

doi:10.1176/jnp.5.4.395

A preliminary study of cortical S₂ serotonin receptors and cognitive performance following stroke

P. L.P. Morris, H. S. Mayberg, K. Bolla, D. F. Wong, R. F. Dannals, S. E. Starkstein, R. G. Robinson

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Abstract

Cortical serotonin receptor binding was measured with positron-emission tomography (PET) in uninjured regions of cortex in 26 stroke patients. Cognitive function was assessed with the Mini-Mental State Exam (MMSE) and a neuropsychological test battery. Left frontal cortex serotonin binding was correlated positively with MMSE total score (r = 0.50, P = 0.01) and with the MMSE concentration, writing, and copying tasks (r = 0.42, 0.56, 0.53, respectively; P < 0.05). Tests of orientation and repetition of difficult phrases were significantly correlated with serotonin binding (r = 0.53 and 0.52, respectively; P < 0.05). These findings suggest that cognitive performance after stroke may be influenced by alterations in the serotonergic system.

Original language	English
Pages (from-to)	395-400
Number of pages	6
Journal	Journal of Neuropsychiatry and Clinical Neurosciences
Volume	5
Issue number	4
DOIs	https://doi.org/10.1176/jnp.5.4.395
State	Published - 1993

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title = "A preliminary study of cortical S2 serotonin receptors and cognitive performance following stroke",

abstract = "Cortical serotonin receptor binding was measured with positron-emission tomography (PET) in uninjured regions of cortex in 26 stroke patients. Cognitive function was assessed with the Mini-Mental State Exam (MMSE) and a neuropsychological test battery. Left frontal cortex serotonin binding was correlated positively with MMSE total score (r = 0.50, P = 0.01) and with the MMSE concentration, writing, and copying tasks (r = 0.42, 0.56, 0.53, respectively; P < 0.05). Tests of orientation and repetition of difficult phrases were significantly correlated with serotonin binding (r = 0.53 and 0.52, respectively; P < 0.05). These findings suggest that cognitive performance after stroke may be influenced by alterations in the serotonergic system.",

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AU - Morris, P. L.P.

AU - Mayberg, H. S.

AU - Bolla, K.

AU - Wong, D. F.

AU - Dannals, R. F.

AU - Starkstein, S. E.

AU - Robinson, R. G.

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AB - Cortical serotonin receptor binding was measured with positron-emission tomography (PET) in uninjured regions of cortex in 26 stroke patients. Cognitive function was assessed with the Mini-Mental State Exam (MMSE) and a neuropsychological test battery. Left frontal cortex serotonin binding was correlated positively with MMSE total score (r = 0.50, P = 0.01) and with the MMSE concentration, writing, and copying tasks (r = 0.42, 0.56, 0.53, respectively; P < 0.05). Tests of orientation and repetition of difficult phrases were significantly correlated with serotonin binding (r = 0.53 and 0.52, respectively; P < 0.05). These findings suggest that cognitive performance after stroke may be influenced by alterations in the serotonergic system.

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A preliminary study of cortical S₂ serotonin receptors and cognitive performance following stroke

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