TY - JOUR
T1 - A pragmatic contouring guideline for salivary gland structures in head and neck radiation oncology
T2 - The MOIST target
AU - Hoebers, Frank
AU - Yu, Eugene
AU - Eisbruch, Avi
AU - Thorstad, Wade
AU - O'sullivan, Brian
AU - Dawson, Laura A.
AU - Hope, Andrew
PY - 2013/2
Y1 - 2013/2
N2 - OBJECTIVES:: One of the main normal tissue toxicities in head and neck radiation oncology is xerostomia. In several studies, reduced radiation dose to the salivary glands has been shown to diminish the effects of gland dysfunction. However, no clear guidelines exist to define the anatomic location of the involved glands on cross-sectional imaging in a pragmatic manner. This study presents an anatomic, computed tomography (CT)-based definition of the major and minor salivary glands. METHODS:: On the basis of information from normal structure anatomy, the location of major and minor salivary glands was identified and translated into a cross-sectional CT-based description of the salivary glands. RESULTS:: The major salivary glands include the parotids and submandibular glands. The minor salivary glands are presented as a part of a surrogate structure (the Minor Oral Including Sublingual Salivary Tissue target), including the minor glands located in the oral mucosa of the tongue, hard and soft palate, buccal mucosa, and inner surface of the lips. CONCLUSIONS:: Clinical implementation of CT-based delineations of the salivary glands according to the proposed guideline should reduce interobserver variability. This may lead to an improved understanding of the relationship between radiation dose and volume and effects on salivary function.
AB - OBJECTIVES:: One of the main normal tissue toxicities in head and neck radiation oncology is xerostomia. In several studies, reduced radiation dose to the salivary glands has been shown to diminish the effects of gland dysfunction. However, no clear guidelines exist to define the anatomic location of the involved glands on cross-sectional imaging in a pragmatic manner. This study presents an anatomic, computed tomography (CT)-based definition of the major and minor salivary glands. METHODS:: On the basis of information from normal structure anatomy, the location of major and minor salivary glands was identified and translated into a cross-sectional CT-based description of the salivary glands. RESULTS:: The major salivary glands include the parotids and submandibular glands. The minor salivary glands are presented as a part of a surrogate structure (the Minor Oral Including Sublingual Salivary Tissue target), including the minor glands located in the oral mucosa of the tongue, hard and soft palate, buccal mucosa, and inner surface of the lips. CONCLUSIONS:: Clinical implementation of CT-based delineations of the salivary glands according to the proposed guideline should reduce interobserver variability. This may lead to an improved understanding of the relationship between radiation dose and volume and effects on salivary function.
KW - intensity modulated radiation treatment
KW - minor salivary glands
KW - normal tissue delineation
KW - salivary anatomy
KW - xerostomia
UR - http://www.scopus.com/inward/record.url?scp=84872948848&partnerID=8YFLogxK
U2 - 10.1097/COC.0b013e31823a538e
DO - 10.1097/COC.0b013e31823a538e
M3 - Article
C2 - 22237147
AN - SCOPUS:84872948848
SN - 0277-3732
VL - 36
SP - 70
EP - 76
JO - American Journal of Clinical Oncology: Cancer Clinical Trials
JF - American Journal of Clinical Oncology: Cancer Clinical Trials
IS - 1
ER -