Rengarajan et al. show that stress in mice causes fecal dysbiosis, which is sufficient to induce diarrhea, intestinal barrier defect, and increased antibacterial IgA. IBS-D patients also display fecal dysbiosis and increased antibacterial IgA that is unique from healthy or IBD patients. This IgA response correlates with somatic symptom severity.

Original languageEnglish
Article number100124
JournalCell Reports Medicine
Issue number7
StatePublished - Oct 20 2020


  • IgA
  • host:commensal immunity
  • irritable bowel syndrome
  • stress


Dive into the research topics of 'A Potential Role for Stress-Induced Microbial Alterations in IgA-Associated Irritable Bowel Syndrome with Diarrhea'. Together they form a unique fingerprint.

Cite this