A potential role for p15(Ink4b) and p57(Kip2) in liver development

Michael M. Awad; Jennifer A. Sanders; Philip A. Gruppuso

doi:10.1016/S0014-5793(00)02108-6

A potential role for p15(Ink4b) and p57(Kip2) in liver development

Michael M. Awad, Jennifer A. Sanders, Philip A. Gruppuso

Section of Minimally Invasive Surgery

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

Hepatocytes undergo marked changes in proliferation during normal liver development. In order to elucidate the mechanism for these changes, we examined the ontogeny of expression for the known cyclin-dependent kinase inhibitors (CKIs), p15(Ink4b), p16(Ink4a), p18(Ink4c), p19(Ink4d), p21(Cip1), p27(Kip1) and p57(Kip2). All except p16(Ink4a) were expressed at some time between late gestation and adulthood. The mRNA and protein expression patterns for p15(Ink4b) and p57(Kip2) were consistent with a role for these CKIs in the regulation of hepatocyte proliferation. Specifically, p57(Kip2) may contribute to hepatocyte growth arrest that occurs in term fetuses, while p15(Ink4b) may contribute to the maintenance of adult hepatocytes in a quiescent state. These results assign a possible role to two CKIs not previously identified as involved in hepatocyte cell cycle control.

Original language	English
Pages (from-to)	160-164
Number of pages	5
Journal	FEBS Letters
Volume	483
Issue number	2-3
DOIs	https://doi.org/10.1016/S0014-5793(00)02108-6
State	Published - Oct 20 2000

Keywords

Cell cycle
Fetal
Hepatocyte
p15(Ink4b)
p21(Cip1)
p57(Kip2)

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10.1016/S0014-5793(00)02108-6

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title = "A potential role for p15(Ink4b) and p57(Kip2) in liver development",

abstract = "Hepatocytes undergo marked changes in proliferation during normal liver development. In order to elucidate the mechanism for these changes, we examined the ontogeny of expression for the known cyclin-dependent kinase inhibitors (CKIs), p15(Ink4b), p16(Ink4a), p18(Ink4c), p19(Ink4d), p21(Cip1), p27(Kip1) and p57(Kip2). All except p16(Ink4a) were expressed at some time between late gestation and adulthood. The mRNA and protein expression patterns for p15(Ink4b) and p57(Kip2) were consistent with a role for these CKIs in the regulation of hepatocyte proliferation. Specifically, p57(Kip2) may contribute to hepatocyte growth arrest that occurs in term fetuses, while p15(Ink4b) may contribute to the maintenance of adult hepatocytes in a quiescent state. These results assign a possible role to two CKIs not previously identified as involved in hepatocyte cell cycle control.",

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doi = "10.1016/S0014-5793(00)02108-6",

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T1 - A potential role for p15(Ink4b) and p57(Kip2) in liver development

AU - Awad, Michael M.

AU - Sanders, Jennifer A.

AU - Gruppuso, Philip A.

PY - 2000/10/20

Y1 - 2000/10/20

N2 - Hepatocytes undergo marked changes in proliferation during normal liver development. In order to elucidate the mechanism for these changes, we examined the ontogeny of expression for the known cyclin-dependent kinase inhibitors (CKIs), p15(Ink4b), p16(Ink4a), p18(Ink4c), p19(Ink4d), p21(Cip1), p27(Kip1) and p57(Kip2). All except p16(Ink4a) were expressed at some time between late gestation and adulthood. The mRNA and protein expression patterns for p15(Ink4b) and p57(Kip2) were consistent with a role for these CKIs in the regulation of hepatocyte proliferation. Specifically, p57(Kip2) may contribute to hepatocyte growth arrest that occurs in term fetuses, while p15(Ink4b) may contribute to the maintenance of adult hepatocytes in a quiescent state. These results assign a possible role to two CKIs not previously identified as involved in hepatocyte cell cycle control.

AB - Hepatocytes undergo marked changes in proliferation during normal liver development. In order to elucidate the mechanism for these changes, we examined the ontogeny of expression for the known cyclin-dependent kinase inhibitors (CKIs), p15(Ink4b), p16(Ink4a), p18(Ink4c), p19(Ink4d), p21(Cip1), p27(Kip1) and p57(Kip2). All except p16(Ink4a) were expressed at some time between late gestation and adulthood. The mRNA and protein expression patterns for p15(Ink4b) and p57(Kip2) were consistent with a role for these CKIs in the regulation of hepatocyte proliferation. Specifically, p57(Kip2) may contribute to hepatocyte growth arrest that occurs in term fetuses, while p15(Ink4b) may contribute to the maintenance of adult hepatocytes in a quiescent state. These results assign a possible role to two CKIs not previously identified as involved in hepatocyte cell cycle control.

KW - Cell cycle

KW - Fetal

KW - Hepatocyte

KW - p15(Ink4b)

KW - p21(Cip1)

KW - p57(Kip2)

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SN - 0014-5793

VL - 483

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JO - FEBS Letters

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IS - 2-3

ER -

A potential role for p15(Ink4b) and p57(Kip2) in liver development

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