A positive-negative mode of population covariation links brain connectivity, demographics and behavior

Stephen M. Smith; Thomas E. Nichols; Diego Vidaurre; Anderson M. Winkler; Timothy E.J. Behrens; Matthew F. Glasser; Kamil Ugurbil; Deanna M. Barch; David C. Van Essen; Karla L. Miller

doi:10.1038/nn.4125

A positive-negative mode of population covariation links brain connectivity, demographics and behavior

Stephen M. Smith, Thomas E. Nichols, Diego Vidaurre, Anderson M. Winkler, Timothy E.J. Behrens, Matthew F. Glasser, Kamil Ugurbil, Deanna M. Barch, David C. Van Essen, Karla L. Miller

Research output: Contribution to journal › Short survey › peer-review

562 Scopus citations

Abstract

We investigated the relationship between individual subjects' functional connectomes and 280 behavioral and demographic measures in a single holistic multivariate analysis relating imaging to non-imaging data from 461 subjects in the Human Connectome Project. We identified one strong mode of population co-variation: subjects were predominantly spread along a single 'positive-negative' axis linking lifestyle, demographic and psychometric measures to each other and to a specific pattern of brain connectivity.

Original language	English
Pages (from-to)	1565-1567
Number of pages	3
Journal	Nature neuroscience
Volume	18
Issue number	11
DOIs	https://doi.org/10.1038/nn.4125
State	Published - Nov 1 2015

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abstract = "We investigated the relationship between individual subjects' functional connectomes and 280 behavioral and demographic measures in a single holistic multivariate analysis relating imaging to non-imaging data from 461 subjects in the Human Connectome Project. We identified one strong mode of population co-variation: subjects were predominantly spread along a single 'positive-negative' axis linking lifestyle, demographic and psychometric measures to each other and to a specific pattern of brain connectivity.",

author = "Smith, {Stephen M.} and Nichols, {Thomas E.} and Diego Vidaurre and Winkler, {Anderson M.} and Behrens, {Timothy E.J.} and Glasser, {Matthew F.} and Kamil Ugurbil and Barch, {Deanna M.} and {Van Essen}, {David C.} and Miller, {Karla L.}",

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AU - Behrens, Timothy E.J.

AU - Glasser, Matthew F.

AU - Ugurbil, Kamil

AU - Barch, Deanna M.

AU - Van Essen, David C.

AU - Miller, Karla L.

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A positive-negative mode of population covariation links brain connectivity, demographics and behavior

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