TY - JOUR
T1 - A pooled analysis of 15 prospective cohort studies on the association between fruit, vegetable, and mature bean consumption and risk of prostate cancer
AU - Petimar, Joshua
AU - Wilson, Kathryn M.
AU - Wu, Kana
AU - Wang, Molin
AU - Albanes, Demetrius
AU - Van Den Brandt, Piet A.
AU - Cook, Michael B.
AU - Giles, Graham G.
AU - Giovannucci, Edward L.
AU - Goodman, Gary E.
AU - Goodman, Phyllis J.
AU - Håkansson, Niclas
AU - Helzlsouer, Kathy
AU - Key, Timothy J.
AU - Kolonel, Laurence N.
AU - Liao, Linda M.
AU - Männistö, Satu
AU - McCullough, Marjorie L.
AU - Milne, Roger L.
AU - Neuhouser, Marian L.
AU - Park, Yikyung
AU - Platz, Elizabeth A.
AU - Riboli, Elio
AU - Sawada, Norie
AU - Schenk, Jeannette M.
AU - Tsugane, Shoichiro
AU - Verhage, Bas
AU - Wang, Ying
AU - Wilkens, Lynne R.
AU - Wolk, Alicja
AU - Ziegler, Regina G.
AU - Smith-Warner, Stephanie A.
N1 - Publisher Copyright:
© 2017 American Association for Cancer Research.
PY - 2017/8
Y1 - 2017/8
N2 - Background: Relationships between fruit, vegetable, and mature bean consumption and prostate cancer risk are unclear. Methods: We examined associations between fruit and vegetable groups, specific fruits and vegetables, and mature bean consumption and prostate cancer risk overall, by stage and grade, and for prostate cancer mortality in a pooled analysis of 15 prospective cohorts, including 52, 680 total cases and 3, 205 prostate cancer-related deaths among 842, 149 men. Diet was measured by a food frequency questionnaire or similar instrument at baseline. We calculated study-specific relative risks using Cox proportional hazards regression, and then pooled these estimates using a random effects model. Results: We did not observe any statistically significant associations for advanced prostate cancer or prostate cancer mortality with any food group (including total fruits and vegetables, total fruits, total vegetables, fruit and vegetable juice, cruciferous vegetables, and tomato products), nor specific fruit and vegetables. In addition, we observed few statistically significant results for other prostate cancer outcomes. Pooled multivariable relative risks comparing the highest versus lowest quantiles across all fruit and vegetable exposures and prostate cancer outcomes ranged from 0.89 to 1.09. There was no evidence of effect modification for any association by age or body mass index. Conclusions: Results from this large, international, pooled analysis do not support a strong role of collective groupings of fruits, vegetables, or mature beans in prostate cancer. Impact: Further investigation of other dietary exposures, especially indicators of bioavailable nutrient intake or specific phytochemicals, should be considered for prostate cancer risk. Cancer Epidemiol Biomarkers Prev; 26(8); 1276-87.
AB - Background: Relationships between fruit, vegetable, and mature bean consumption and prostate cancer risk are unclear. Methods: We examined associations between fruit and vegetable groups, specific fruits and vegetables, and mature bean consumption and prostate cancer risk overall, by stage and grade, and for prostate cancer mortality in a pooled analysis of 15 prospective cohorts, including 52, 680 total cases and 3, 205 prostate cancer-related deaths among 842, 149 men. Diet was measured by a food frequency questionnaire or similar instrument at baseline. We calculated study-specific relative risks using Cox proportional hazards regression, and then pooled these estimates using a random effects model. Results: We did not observe any statistically significant associations for advanced prostate cancer or prostate cancer mortality with any food group (including total fruits and vegetables, total fruits, total vegetables, fruit and vegetable juice, cruciferous vegetables, and tomato products), nor specific fruit and vegetables. In addition, we observed few statistically significant results for other prostate cancer outcomes. Pooled multivariable relative risks comparing the highest versus lowest quantiles across all fruit and vegetable exposures and prostate cancer outcomes ranged from 0.89 to 1.09. There was no evidence of effect modification for any association by age or body mass index. Conclusions: Results from this large, international, pooled analysis do not support a strong role of collective groupings of fruits, vegetables, or mature beans in prostate cancer. Impact: Further investigation of other dietary exposures, especially indicators of bioavailable nutrient intake or specific phytochemicals, should be considered for prostate cancer risk. Cancer Epidemiol Biomarkers Prev; 26(8); 1276-87.
UR - http://www.scopus.com/inward/record.url?scp=85026818017&partnerID=8YFLogxK
U2 - 10.1158/1055-9965.EPI-16-1006
DO - 10.1158/1055-9965.EPI-16-1006
M3 - Article
C2 - 28446545
AN - SCOPUS:85026818017
SN - 1055-9965
VL - 26
SP - 1276
EP - 1287
JO - Cancer Epidemiology Biomarkers and Prevention
JF - Cancer Epidemiology Biomarkers and Prevention
IS - 8
ER -