TY - JOUR
T1 - A pilot study of urokinase therapy in cerebral infarction
AU - Fletcher, Anthony P.
AU - Alkjaersig, Norma
AU - Lewis, Martin
AU - Tulevski, Vasil
AU - Davies, Andrew
AU - Brooks, John E.
AU - Hardin, William B.
AU - Landau, William M.
AU - Raichle, Marcus E.
PY - 1976
Y1 - 1976
N2 - Thirty-one patients with acute cerebral infarction were treated with the thrombolytic agent urokinase for either a single or a double infusion period, each of ten hours. The effects of urokinase therapy administered at dosage rates of 1,200, 1.500 or 1,700 (TA urokinase units per pound of body weight per hour were followed by serial blood coagulation and other biochemical studies. In the dosage used, urokinase produced a prompt sustained increase, 20-fold to 40-fold, of plasma thrombolytic activity with relatively minor disturbance of the blood coagulation system. Never-theless. hemorrhagic complications occurred in several patients and distinctly favorable therapeutic effects were not observed.
AB - Thirty-one patients with acute cerebral infarction were treated with the thrombolytic agent urokinase for either a single or a double infusion period, each of ten hours. The effects of urokinase therapy administered at dosage rates of 1,200, 1.500 or 1,700 (TA urokinase units per pound of body weight per hour were followed by serial blood coagulation and other biochemical studies. In the dosage used, urokinase produced a prompt sustained increase, 20-fold to 40-fold, of plasma thrombolytic activity with relatively minor disturbance of the blood coagulation system. Never-theless. hemorrhagic complications occurred in several patients and distinctly favorable therapeutic effects were not observed.
UR - http://www.scopus.com/inward/record.url?scp=0017285123&partnerID=8YFLogxK
U2 - 10.1161/01.STR.7.2.135
DO - 10.1161/01.STR.7.2.135
M3 - Article
C2 - 1265805
AN - SCOPUS:0017285123
SN - 0039-2499
VL - 7
SP - 135
EP - 142
JO - Stroke
JF - Stroke
IS - 2
ER -