A pilot study for evaluation of hypotonia in children with neurofibromatosis type 1

Elizabeth A. Soucy, Lauren E. Wessel, Feng Gao, Anne C. Albers, David H. Gutmann, Courtney M. Dunn

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

There are currently no objective criteria to evaluate pediatric hypotonia. The purpose of this pilot study was to identify diagnostic criteria for assessing hypotonia in children with neurofibromatosis type 1. Fifty-five subjects between the ages of 1 and 7 years with a diagnosis of neurofibromatosis type 1 were evaluated. A physical therapist recorded a subjective tone assessment and objective tone metrics, including ankle dorsiflexion, knee extension, hip abduction, triceps fat percentage, grip strength, and head lag during a pull-to-sit test. Multivariate logistic regression analysis showed the presence of head lag paired with increased hip range of motion was a significant predictor of hypotonia. The presence of head lag on a pull-to-sit test paired with increased hip range of motion is an accurate predictor of hypotonia in children with neurofibromatosis type 1. These objective measures should be prospectively evaluated in other pediatric populations for their ability to predict hypotonia.

Original languageEnglish
Pages (from-to)382-385
Number of pages4
JournalJournal of Child Neurology
Volume30
Issue number3
DOIs
StatePublished - Mar 26 2015

Keywords

  • grip strength
  • head lag
  • hip abduction
  • hypotonia
  • muscle tone
  • neurofibromatosis type 1

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