A pilot phase II trial of magnesium supplements to reduce menopausal hot flashes in breast cancer patients

Haeseong Park, Gwendolyn L. Parker, Cecelia H. Boardman, Monica M. Morris, Thomas J. Smith

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


Background We tested if magnesium would diminish bothersome hot flashes in breast cancer patients. Methods Breast cancer patients with at least 14 hot flashes a week received magnesium oxide 400 mg for 4 weeks, escalating to 800 mg if needed. Hot flash score (frequency× severity) at baseline was compared to the end of treatment. Results Of 29 who enrolled, 25 women completed treatment. The average age was 53.5 years; six African American, the rest Caucasian; eight were on tamoxifen, nine were on aromatase inhibitors, and 14 were on antidepressants. Seventeen patients escalated the magnesium dose. Hot flash frequency/week was reduced from 52.2 (standard error (SE), 13.7) to 27.7 (SE, 5.7), a 41.4% reduction, p=0.02, two-sided paired t test. Hot flash score was reduced from 109.8 (SE, 40.9) to 47.8 (SE, 13.8), a 50.4% reduction, p=0.04. Of 25 patients, 14 (56%) had a >50% reduction in hot flash score, and 19 (76%) had a >25% reduction. Fatigue, sweating, and distress were all significantly reduced. Side effects were minor: two women stopped the drug including one each with headache and nausea, and two women had grade 1 diarrhea. Compliance was excellent, and many patients continued treatment after the trial. Conclusions Oral magnesium appears to have helped more than half of the patients and was well tolerated. Side effects and cost ($0.02/tablet) were minimal. A randomized placebo-controlled trial is planned.

Original languageEnglish
Pages (from-to)859-863
Number of pages5
JournalSupportive Care in Cancer
Issue number6
StatePublished - Jun 2011


  • Breast cancer
  • Drug treatment
  • Hot flashes
  • Menopause
  • Survivorship


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