A physical map of the mouse genome

Simon G. Gregory, Mandeep Sekhon, Jacqueline Schein, Shaying Zhao, Kazutoyo Osoegawa, Carol E. Scott, Richard S. Evans, Paul W. Burridge, Tony V. Cox, Christopher A. Fox, Richard D. Hutton, Ian R. Mulienger, Kimbly J. Phillips, James Smith, Jim Stalker, Glen J. Threadgold, Ewan Birney, Kristine Wylie, Asif Chinwalia, John WallisLa Deana Hillier, Jason Carter, Tony Galge, Sara Jaeger, Colin Kremitzki, Dan Layman, Jason Maas, Rebecca McGrane, Kelly Mead, Rebecca Walker, Steven Jones, Michael Smith, Jennifer Asano, Ian Bosdet, Susanna Chan, Suganthi Chittaranjan, Readman Chiu, Chris Fjeil, Dan Fuhrmann, Noreen Girn, Catharine Gray, Ran Guin, Letticia Hsiao, Martin Krzywinski, Reta Kutsche, Soo Sen Lee, Carrie Mathewson, Candice McLeavy, Steven Messervier, Steven Ness, Pawan Pandoh, Anna Liisa Prabhu, Parvaneh Saeedi, Duane Smallus, Lorraine Spence, Jeff Stott, Sheryl Taylor, Wesley Terpstra, Miranda Tsai, Jill Vardy, Natasja Wye, George Yang, Sofiya Shatsman, Bola Ayodeji, Kelta Geer, Getahun Tsegaye, Alla Shvartsbeyn, Elizabeth Gebregeorgis, Margaret Kroi, Daniel Russell, Larry Overton, Joel A. Malek, Mike Holmes, Michael Heaney, Jyoti Shetty, Tamara Feldblyum, William C. Nierman, Joseph J. Catanese, Tim Hubbard, Robert H. Waterston, Jane Rogers, Pieter J. De Jong, Claire M. Fraser, John D. McPherson, David R. Bentley

Research output: Contribution to journalArticlepeer-review

268 Scopus citations


A physical map of a genome is an essential guide for navigation, allowing the location of any gene or other landmark in the chromosomal DNA. We have constructed a physical map of the mouse genome that contains 296 contigs of overlapping bacterial clones and 16, 992 unique markers. The mouse contigs were aligned to the human genome sequence on the basis of 51, 486 homology matches, thus enabling use of the conserved synteny (correspondence between chromosome blocks) of the two genomes to accelerate construction of the mouse map. The map provides a framework for assembly of whole-genome shotgun sequence data, and a tile path of clones for generation of the reference sequence. Definition of the human-mouse alignment at this level of resolution enables identification of a mouse clone that corresponds to almost any position in the human genome. The human sequence may be used to facilitate construction of other mammalian genome maps using the same strategy.

Original languageEnglish
Pages (from-to)743-750
Number of pages8
Issue number6899
StatePublished - Aug 15 2002


Dive into the research topics of 'A physical map of the mouse genome'. Together they form a unique fingerprint.

Cite this