A physical map of the human genome

John D. McPherson; Marco Marra; La Deana Hillier; Robert H. Waterston; Asif Chinwalla; John Wallis; Mandeep Sekhon; Kristine Wylie; Elaine R. Mardis; Richard K. Wilson; Robert Fulton; Tamara A. Kucaba; Caryn Wagner-McPherson; William B. Barbazuk; Simon G. Gregory; Sean J. Humphray; Lisa French; Richard S. Evans; Graeme Bethel; Adam Whittaker; Jane L. Holden; Owen T. McCann; Andrew Dunham; Carol Soderlund; Carol E. Scott; David R. Bentley; Gregory Schuler; Hsiu Chuan Chen; Wonhee Jang; Eric D. Green; Jacquelyn R. Idol; Valerie V.Braden Maduro; Kate T. Montgomery; Eunice Lee; Ashley Miller; Suzanne Emerling; Raju Kucherlapati; Richard Gibbs; Steve Scherer; J. Harley Gorrell; Erica Sodergren; Kerstin Clerc-Blankenburg; Paul Tabor; Susan Naylor; Dawn Garcia; J. de Jong; Joseph J. Catanese; Norma Nowak; Kazutoyo Osoegawa; Shizhen Qin; Lee Rowen; Anuradha Madan; Monica Dors; Leroy Hood; Barbara Trask; Cynthia Friedman; Hillary Massa; Vivian G. Cheung; Ilan R. Kirsch; Thomas Reid; Raluca Yonescu; Jean Weissenbach; Thomas Bruls; Roland Heilig; Elbert Branscomb; Anne Olsen; Norman Doggett; Jan Fang Cheng; Trevor Hawkins; Richard M. Myers; Jin Shang; Lucia Ramirez; Jeremy Schmutz; Olivia Velasquez; Kami Dixon; Nancy E. Stone; David R. Cox; David Haussler; W. James Kent; Terrence Furey; Sanja Rogic; Scot Kennedy; Steven Jones; André Rosenthal; Gaiping Wen; Markus Schilhabel; Gernot Gloeckner; Gerald Nyakatura; Reiner Siebert; Brigitte Schlegelberger; Julie Korenberg; Xiao Ning Chen; Asao Fujiyama; Masahira Hattori; Atsushi Toyoda; Tetsushi Yada; Hong Seok Park; Yoshiyuki Sakaki; Nobuyoshi Shimizu; Shuichi Asakawa; Kazuhiko Kawasaki; Takashi Sasaki; Ai Shintani; Atsushi Shimizu; Kazunori Shibuya; Jun Kudoh; Shinsei Minoshima; Juliane Ramser; Peter Seranski; Celine Hoff; Annemarie Poustka; Richard Reinhardt; Hans Lehrach

doi:10.1038/35057157

A physical map of the human genome

John D. McPherson, Marco Marra, La Deana Hillier, Robert H. Waterston, Asif Chinwalla, John Wallis, Mandeep Sekhon, Kristine Wylie, Elaine R. Mardis, Richard K. Wilson, Robert Fulton, Tamara A. Kucaba, Caryn Wagner-McPherson, William B. Barbazuk, Simon G. Gregory, Sean J. Humphray, Lisa French, Richard S. Evans, Graeme Bethel, Adam WhittakerJane L. Holden, Owen T. McCann, Andrew Dunham, Carol Soderlund, Carol E. Scott, David R. Bentley, Gregory Schuler, Hsiu Chuan Chen, Wonhee Jang, Eric D. Green, Jacquelyn R. Idol, Valerie V.Braden Maduro, Kate T. Montgomery, Eunice Lee, Ashley Miller, Suzanne Emerling, Raju Kucherlapati, Richard Gibbs, Steve Scherer, J. Harley Gorrell, Erica Sodergren, Kerstin Clerc-Blankenburg, Paul Tabor, Susan Naylor, Dawn Garcia, J. de Jong, Joseph J. Catanese, Norma Nowak, Kazutoyo Osoegawa, Shizhen Qin, Lee Rowen, Anuradha Madan, Monica Dors, Leroy Hood, Barbara Trask, Cynthia Friedman, Hillary Massa, Vivian G. Cheung, Ilan R. Kirsch, Thomas Reid, Raluca Yonescu, Jean Weissenbach, Thomas Bruls, Roland Heilig, Elbert Branscomb, Anne Olsen, Norman Doggett, Jan Fang Cheng, Trevor Hawkins, Richard M. Myers, Jin Shang, Lucia Ramirez, Jeremy Schmutz, Olivia Velasquez, Kami Dixon, Nancy E. Stone, David R. Cox, David Haussler, W. James Kent, Terrence Furey, Sanja Rogic, Scot Kennedy, Steven Jones, André Rosenthal, Gaiping Wen, Markus Schilhabel, Gernot Gloeckner, Gerald Nyakatura, Reiner Siebert, Brigitte Schlegelberger, Julie Korenberg, Xiao Ning Chen, Asao Fujiyama, Masahira Hattori, Atsushi Toyoda, Tetsushi Yada, Hong Seok Park, Yoshiyuki Sakaki, Nobuyoshi Shimizu, Shuichi Asakawa, Kazuhiko Kawasaki, Takashi Sasaki, Ai Shintani, Atsushi Shimizu, Kazunori Shibuya, Jun Kudoh, Shinsei Minoshima, Juliane Ramser, Peter Seranski, Celine Hoff, Annemarie Poustka, Richard Reinhardt, Hans Lehrach

Research output: Contribution to journal › Article

671 Scopus citations

Abstract

The human genome is by far the largest genome to be sequenced, and its size and complexity present many challenges for sequence assembly. The International Human Genome Sequencing Consortium constructed a map of the whole genome to enable the selection of clones for sequencing and for the accurate assembly of the genome sequence. Here we report the construction of the whole-genome bacterial artificial chromosome (BAC) map and its integration with previous landmark maps and information from mapping efforts focused on specific chromosomal regions. We also describe the integration of sequence data with the map.

Original language	English
Pages (from-to)	934-941
Number of pages	8
Journal	Nature
Volume	409
Issue number	6822
DOIs	https://doi.org/10.1038/35057157
State	Published - Feb 15 2001

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McPherson, J. D., Marra, M., Hillier, L. D., Waterston, R. H., Chinwalla, A., Wallis, J., Sekhon, M., Wylie, K., Mardis, E. R., Wilson, R. K., Fulton, R., Kucaba, T. A., Wagner-McPherson, C., Barbazuk, W. B., Gregory, S. G., Humphray, S. J., French, L., Evans, R. S., Bethel, G., ... Lehrach, H. (2001). A physical map of the human genome. Nature, 409(6822), 934-941. https://doi.org/10.1038/35057157

McPherson, John D. ; Marra, Marco ; Hillier, La Deana ; Waterston, Robert H. ; Chinwalla, Asif ; Wallis, John ; Sekhon, Mandeep ; Wylie, Kristine ; Mardis, Elaine R. ; Wilson, Richard K. ; Fulton, Robert ; Kucaba, Tamara A. ; Wagner-McPherson, Caryn ; Barbazuk, William B. ; Gregory, Simon G. ; Humphray, Sean J. ; French, Lisa ; Evans, Richard S. ; Bethel, Graeme ; Whittaker, Adam ; Holden, Jane L. ; McCann, Owen T. ; Dunham, Andrew ; Soderlund, Carol ; Scott, Carol E. ; Bentley, David R. ; Schuler, Gregory ; Chen, Hsiu Chuan ; Jang, Wonhee ; Green, Eric D. ; Idol, Jacquelyn R. ; Maduro, Valerie V.Braden ; Montgomery, Kate T. ; Lee, Eunice ; Miller, Ashley ; Emerling, Suzanne ; Kucherlapati, Raju ; Gibbs, Richard ; Scherer, Steve ; Gorrell, J. Harley ; Sodergren, Erica ; Clerc-Blankenburg, Kerstin ; Tabor, Paul ; Naylor, Susan ; Garcia, Dawn ; de Jong, J. ; Catanese, Joseph J. ; Nowak, Norma ; Osoegawa, Kazutoyo ; Qin, Shizhen ; Rowen, Lee ; Madan, Anuradha ; Dors, Monica ; Hood, Leroy ; Trask, Barbara ; Friedman, Cynthia ; Massa, Hillary ; Cheung, Vivian G. ; Kirsch, Ilan R. ; Reid, Thomas ; Yonescu, Raluca ; Weissenbach, Jean ; Bruls, Thomas ; Heilig, Roland ; Branscomb, Elbert ; Olsen, Anne ; Doggett, Norman ; Cheng, Jan Fang ; Hawkins, Trevor ; Myers, Richard M. ; Shang, Jin ; Ramirez, Lucia ; Schmutz, Jeremy ; Velasquez, Olivia ; Dixon, Kami ; Stone, Nancy E. ; Cox, David R. ; Haussler, David ; Kent, W. James ; Furey, Terrence ; Rogic, Sanja ; Kennedy, Scot ; Jones, Steven ; Rosenthal, André ; Wen, Gaiping ; Schilhabel, Markus ; Gloeckner, Gernot ; Nyakatura, Gerald ; Siebert, Reiner ; Schlegelberger, Brigitte ; Korenberg, Julie ; Chen, Xiao Ning ; Fujiyama, Asao ; Hattori, Masahira ; Toyoda, Atsushi ; Yada, Tetsushi ; Park, Hong Seok ; Sakaki, Yoshiyuki ; Shimizu, Nobuyoshi ; Asakawa, Shuichi ; Kawasaki, Kazuhiko ; Sasaki, Takashi ; Shintani, Ai ; Shimizu, Atsushi ; Shibuya, Kazunori ; Kudoh, Jun ; Minoshima, Shinsei ; Ramser, Juliane ; Seranski, Peter ; Hoff, Celine ; Poustka, Annemarie ; Reinhardt, Richard ; Lehrach, Hans. / A physical map of the human genome. In: Nature. 2001 ; Vol. 409, No. 6822. pp. 934-941.

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abstract = "The human genome is by far the largest genome to be sequenced, and its size and complexity present many challenges for sequence assembly. The International Human Genome Sequencing Consortium constructed a map of the whole genome to enable the selection of clones for sequencing and for the accurate assembly of the genome sequence. Here we report the construction of the whole-genome bacterial artificial chromosome (BAC) map and its integration with previous landmark maps and information from mapping efforts focused on specific chromosomal regions. We also describe the integration of sequence data with the map.",

author = "McPherson, {John D.} and Marco Marra and Hillier, {La Deana} and Waterston, {Robert H.} and Asif Chinwalla and John Wallis and Mandeep Sekhon and Kristine Wylie and Mardis, {Elaine R.} and Wilson, {Richard K.} and Robert Fulton and Kucaba, {Tamara A.} and Caryn Wagner-McPherson and Barbazuk, {William B.} and Gregory, {Simon G.} and Humphray, {Sean J.} and Lisa French and Evans, {Richard S.} and Graeme Bethel and Adam Whittaker and Holden, {Jane L.} and McCann, {Owen T.} and Andrew Dunham and Carol Soderlund and Scott, {Carol E.} and Bentley, {David R.} and Gregory Schuler and Chen, {Hsiu Chuan} and Wonhee Jang and Green, {Eric D.} and Idol, {Jacquelyn R.} and Maduro, {Valerie V.Braden} and Montgomery, {Kate T.} and Eunice Lee and Ashley Miller and Suzanne Emerling and Raju Kucherlapati and Richard Gibbs and Steve Scherer and Gorrell, {J. Harley} and Erica Sodergren and Kerstin Clerc-Blankenburg and Paul Tabor and Susan Naylor and Dawn Garcia and {de Jong}, J. and Catanese, {Joseph J.} and Norma Nowak and Kazutoyo Osoegawa and Shizhen Qin and Lee Rowen and Anuradha Madan and Monica Dors and Leroy Hood and Barbara Trask and Cynthia Friedman and Hillary Massa and Cheung, {Vivian G.} and Kirsch, {Ilan R.} and Thomas Reid and Raluca Yonescu and Jean Weissenbach and Thomas Bruls and Roland Heilig and Elbert Branscomb and Anne Olsen and Norman Doggett and Cheng, {Jan Fang} and Trevor Hawkins and Myers, {Richard M.} and Jin Shang and Lucia Ramirez and Jeremy Schmutz and Olivia Velasquez and Kami Dixon and Stone, {Nancy E.} and Cox, {David R.} and David Haussler and Kent, {W. James} and Terrence Furey and Sanja Rogic and Scot Kennedy and Steven Jones and Andr{\'e} Rosenthal and Gaiping Wen and Markus Schilhabel and Gernot Gloeckner and Gerald Nyakatura and Reiner Siebert and Brigitte Schlegelberger and Julie Korenberg and Chen, {Xiao Ning} and Asao Fujiyama and Masahira Hattori and Atsushi Toyoda and Tetsushi Yada and Park, {Hong Seok} and Yoshiyuki Sakaki and Nobuyoshi Shimizu and Shuichi Asakawa and Kazuhiko Kawasaki and Takashi Sasaki and Ai Shintani and Atsushi Shimizu and Kazunori Shibuya and Jun Kudoh and Shinsei Minoshima and Juliane Ramser and Peter Seranski and Celine Hoff and Annemarie Poustka and Richard Reinhardt and Hans Lehrach",

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doi = "10.1038/35057157",

language = "English",

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pages = "934--941",

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McPherson, JD, Marra, M, Hillier, LD, Waterston, RH, Chinwalla, A, Wallis, J, Sekhon, M, Wylie, K, Mardis, ER, Wilson, RK, Fulton, R, Kucaba, TA, Wagner-McPherson, C, Barbazuk, WB, Gregory, SG, Humphray, SJ, French, L, Evans, RS, Bethel, G, Whittaker, A, Holden, JL, McCann, OT, Dunham, A, Soderlund, C, Scott, CE, Bentley, DR, Schuler, G, Chen, HC, Jang, W, Green, ED, Idol, JR, Maduro, VVB, Montgomery, KT, Lee, E, Miller, A, Emerling, S, Kucherlapati, R, Gibbs, R, Scherer, S, Gorrell, JH, Sodergren, E, Clerc-Blankenburg, K, Tabor, P, Naylor, S, Garcia, D, de Jong, J, Catanese, JJ, Nowak, N, Osoegawa, K, Qin, S, Rowen, L, Madan, A, Dors, M, Hood, L, Trask, B, Friedman, C, Massa, H, Cheung, VG, Kirsch, IR, Reid, T, Yonescu, R, Weissenbach, J, Bruls, T, Heilig, R, Branscomb, E, Olsen, A, Doggett, N, Cheng, JF, Hawkins, T, Myers, RM, Shang, J, Ramirez, L, Schmutz, J, Velasquez, O, Dixon, K, Stone, NE, Cox, DR, Haussler, D, Kent, WJ, Furey, T, Rogic, S, Kennedy, S, Jones, S, Rosenthal, A, Wen, G, Schilhabel, M, Gloeckner, G, Nyakatura, G, Siebert, R, Schlegelberger, B, Korenberg, J, Chen, XN, Fujiyama, A, Hattori, M, Toyoda, A, Yada, T, Park, HS, Sakaki, Y, Shimizu, N, Asakawa, S, Kawasaki, K, Sasaki, T, Shintani, A, Shimizu, A, Shibuya, K, Kudoh, J, Minoshima, S, Ramser, J, Seranski, P, Hoff, C, Poustka, A, Reinhardt, R & Lehrach, H 2001, 'A physical map of the human genome', Nature, vol. 409, no. 6822, pp. 934-941. https://doi.org/10.1038/35057157

A physical map of the human genome. / McPherson, John D.; Marra, Marco; Hillier, La Deana; Waterston, Robert H.; Chinwalla, Asif; Wallis, John; Sekhon, Mandeep; Wylie, Kristine; Mardis, Elaine R.; Wilson, Richard K.; Fulton, Robert; Kucaba, Tamara A.; Wagner-McPherson, Caryn; Barbazuk, William B.; Gregory, Simon G.; Humphray, Sean J.; French, Lisa; Evans, Richard S.; Bethel, Graeme; Whittaker, Adam; Holden, Jane L.; McCann, Owen T.; Dunham, Andrew; Soderlund, Carol; Scott, Carol E.; Bentley, David R.; Schuler, Gregory; Chen, Hsiu Chuan; Jang, Wonhee; Green, Eric D.; Idol, Jacquelyn R.; Maduro, Valerie V.Braden; Montgomery, Kate T.; Lee, Eunice; Miller, Ashley; Emerling, Suzanne; Kucherlapati, Raju; Gibbs, Richard; Scherer, Steve; Gorrell, J. Harley; Sodergren, Erica; Clerc-Blankenburg, Kerstin; Tabor, Paul; Naylor, Susan; Garcia, Dawn; de Jong, J.; Catanese, Joseph J.; Nowak, Norma; Osoegawa, Kazutoyo; Qin, Shizhen; Rowen, Lee; Madan, Anuradha; Dors, Monica; Hood, Leroy; Trask, Barbara; Friedman, Cynthia; Massa, Hillary; Cheung, Vivian G.; Kirsch, Ilan R.; Reid, Thomas; Yonescu, Raluca; Weissenbach, Jean; Bruls, Thomas; Heilig, Roland; Branscomb, Elbert; Olsen, Anne; Doggett, Norman; Cheng, Jan Fang; Hawkins, Trevor; Myers, Richard M.; Shang, Jin; Ramirez, Lucia; Schmutz, Jeremy; Velasquez, Olivia; Dixon, Kami; Stone, Nancy E.; Cox, David R.; Haussler, David; Kent, W. James; Furey, Terrence; Rogic, Sanja; Kennedy, Scot; Jones, Steven; Rosenthal, André; Wen, Gaiping; Schilhabel, Markus; Gloeckner, Gernot; Nyakatura, Gerald; Siebert, Reiner; Schlegelberger, Brigitte; Korenberg, Julie; Chen, Xiao Ning; Fujiyama, Asao; Hattori, Masahira; Toyoda, Atsushi; Yada, Tetsushi; Park, Hong Seok; Sakaki, Yoshiyuki; Shimizu, Nobuyoshi; Asakawa, Shuichi; Kawasaki, Kazuhiko; Sasaki, Takashi; Shintani, Ai; Shimizu, Atsushi; Shibuya, Kazunori; Kudoh, Jun; Minoshima, Shinsei; Ramser, Juliane; Seranski, Peter; Hoff, Celine; Poustka, Annemarie; Reinhardt, Richard; Lehrach, Hans.

In: Nature, Vol. 409, No. 6822, 15.02.2001, p. 934-941.

Research output: Contribution to journal › Article

TY - JOUR

T1 - A physical map of the human genome

AU - McPherson, John D.

AU - Marra, Marco

AU - Hillier, La Deana

AU - Waterston, Robert H.

AU - Chinwalla, Asif

AU - Wallis, John

AU - Sekhon, Mandeep

AU - Wylie, Kristine

AU - Mardis, Elaine R.

AU - Wilson, Richard K.

AU - Fulton, Robert

AU - Kucaba, Tamara A.

AU - Wagner-McPherson, Caryn

AU - Barbazuk, William B.

AU - Gregory, Simon G.

AU - Humphray, Sean J.

AU - French, Lisa

AU - Evans, Richard S.

AU - Bethel, Graeme

AU - Whittaker, Adam

AU - Holden, Jane L.

AU - McCann, Owen T.

AU - Dunham, Andrew

AU - Soderlund, Carol

AU - Scott, Carol E.

AU - Bentley, David R.

AU - Schuler, Gregory

AU - Chen, Hsiu Chuan

AU - Jang, Wonhee

AU - Green, Eric D.

AU - Idol, Jacquelyn R.

AU - Maduro, Valerie V.Braden

AU - Montgomery, Kate T.

AU - Lee, Eunice

AU - Miller, Ashley

AU - Emerling, Suzanne

AU - Kucherlapati, Raju

AU - Gibbs, Richard

AU - Scherer, Steve

AU - Gorrell, J. Harley

AU - Sodergren, Erica

AU - Clerc-Blankenburg, Kerstin

AU - Tabor, Paul

AU - Naylor, Susan

AU - Garcia, Dawn

AU - de Jong, J.

AU - Catanese, Joseph J.

AU - Nowak, Norma

AU - Osoegawa, Kazutoyo

AU - Qin, Shizhen

AU - Rowen, Lee

AU - Madan, Anuradha

AU - Dors, Monica

AU - Hood, Leroy

AU - Trask, Barbara

AU - Friedman, Cynthia

AU - Massa, Hillary

AU - Cheung, Vivian G.

AU - Kirsch, Ilan R.

AU - Reid, Thomas

AU - Yonescu, Raluca

AU - Weissenbach, Jean

AU - Bruls, Thomas

AU - Heilig, Roland

AU - Branscomb, Elbert

AU - Olsen, Anne

AU - Doggett, Norman

AU - Cheng, Jan Fang

AU - Hawkins, Trevor

AU - Myers, Richard M.

AU - Shang, Jin

AU - Ramirez, Lucia

AU - Schmutz, Jeremy

AU - Velasquez, Olivia

AU - Dixon, Kami

AU - Stone, Nancy E.

AU - Cox, David R.

AU - Haussler, David

AU - Kent, W. James

AU - Furey, Terrence

AU - Rogic, Sanja

AU - Kennedy, Scot

AU - Jones, Steven

AU - Rosenthal, André

AU - Wen, Gaiping

AU - Schilhabel, Markus

AU - Gloeckner, Gernot

AU - Nyakatura, Gerald

AU - Siebert, Reiner

AU - Schlegelberger, Brigitte

AU - Korenberg, Julie

AU - Chen, Xiao Ning

AU - Fujiyama, Asao

AU - Hattori, Masahira

AU - Toyoda, Atsushi

AU - Yada, Tetsushi

AU - Park, Hong Seok

AU - Sakaki, Yoshiyuki

AU - Shimizu, Nobuyoshi

AU - Asakawa, Shuichi

AU - Kawasaki, Kazuhiko

AU - Sasaki, Takashi

AU - Shintani, Ai

AU - Shimizu, Atsushi

AU - Shibuya, Kazunori

AU - Kudoh, Jun

AU - Minoshima, Shinsei

AU - Ramser, Juliane

AU - Seranski, Peter

AU - Hoff, Celine

AU - Poustka, Annemarie

AU - Reinhardt, Richard

AU - Lehrach, Hans

PY - 2001/2/15

Y1 - 2001/2/15

N2 - The human genome is by far the largest genome to be sequenced, and its size and complexity present many challenges for sequence assembly. The International Human Genome Sequencing Consortium constructed a map of the whole genome to enable the selection of clones for sequencing and for the accurate assembly of the genome sequence. Here we report the construction of the whole-genome bacterial artificial chromosome (BAC) map and its integration with previous landmark maps and information from mapping efforts focused on specific chromosomal regions. We also describe the integration of sequence data with the map.

AB - The human genome is by far the largest genome to be sequenced, and its size and complexity present many challenges for sequence assembly. The International Human Genome Sequencing Consortium constructed a map of the whole genome to enable the selection of clones for sequencing and for the accurate assembly of the genome sequence. Here we report the construction of the whole-genome bacterial artificial chromosome (BAC) map and its integration with previous landmark maps and information from mapping efforts focused on specific chromosomal regions. We also describe the integration of sequence data with the map.

UR - http://www.scopus.com/inward/record.url?scp=0035865087&partnerID=8YFLogxK

U2 - 10.1038/35057157

DO - 10.1038/35057157

M3 - Article

C2 - 11237014

AN - SCOPUS:0035865087

VL - 409

SP - 934

EP - 941

JO - Nature

JF - Nature

SN - 0028-0836

IS - 6822

ER -