@article{dba090e1deb4484cbb896fef4275f5b4,
title = "A Phenome-Wide Association Study (PheWAS) of Late Onset Alzheimer Disease Genetic Risk in Children of European Ancestry at Middle Childhood: Results from the ABCD Study",
abstract = "Genetic risk for Late Onset Alzheimer Disease (AD) has been associated with lower cognition and smaller hippocampal volume in healthy young adults. However, whether these and other associations are present during childhood remains unclear. Using data from 5556 genomically-confirmed European ancestry youth who completed the baseline session of the ongoing the Adolescent Brain Cognitive DevelopmentSM Study (ABCD Study{\textregistered}), our phenome-wide association study estimating associations between four indices of genetic risk for late-onset AD (i.e., AD polygenic risk scores (PRS), APOE rs429358 genotype, AD PRS with the APOE region removed (ADPRS-APOE), and an interaction between ADPRS-APOE and APOE genotype) and 1687 psychosocial, behavioral, and neural phenotypes revealed no significant associations after correction for multiple testing (all ps > 0.0002; all pfdr > 0.07). These data suggest that AD genetic risk may not phenotypically manifest during middle-childhood or that effects are smaller than this sample is powered to detect.",
keywords = "APOE, Alzheimer disease, Imaging, Middle childhood, Phenome-wide association study, Polygenic risk scores",
author = "Gorelik, {Aaron J.} and Paul, {Sarah E.} and Karcher, {Nicole R.} and Johnson, {Emma C.} and Isha Nagella and Lauren Blaydon and Hailey Modi and Hansen, {Isabella S.} and Colbert, {Sarah M.C.} and Baranger, {David A.A.} and Norton, {Sara A.} and Isaiah Spears and Brian Gordon and Wei Zhang and Hill, {Patrick L.} and Oltmanns, {Thomas F.} and Bijsterbosch, {Janine D.} and Arpana Agrawal and Hatoum, {Alexander S.} and Ryan Bogdan",
note = "Funding Information: This study was funded by R01DA054750 (RB, AA). AJG was supported by NSF DGE-213989. SEP was supported by F31AA029934. NRK was supported by K23MH12179201. ECJ was supported by K01DA051759. ASH was supported by K01AA030083. Data for this study were provided by the Adolescent Brain Cognitive Development (ABCD) study, which was funded by the National Institutes of Health (grants U01DA041022, U01DA041025, U01DA041028, U01DA041048, U01DA041089, U01DA041093, U01DA041106, U01DA041117, U01DA041120, U01DA041134, U01DA041148, U01DA041156, U01DA041174, U24DA041123, and U24DA041147) and additional federal partners ( https://abcdstudy.org/federal-partners.html ). Publisher Copyright: {\textcopyright} 2023, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.",
year = "2023",
month = may,
doi = "10.1007/s10519-023-10140-3",
language = "English",
volume = "53",
pages = "249--264",
journal = "Behavior genetics",
issn = "0001-8244",
number = "3",
}