A Phase II Study of Plerixafor (AMD3100) plus G-CSF for Autologous Hematopoietic Progenitor Cell Mobilization in Patients with Hodgkin Lymphoma

Amanda Cashen, Sandra Lopez, Feng Gao, Gary Calandra, Ron MacFarland, Karin Badel, John DiPersio

Research output: Contribution to journalArticlepeer-review

112 Scopus citations

Abstract

Collection of an adequate number of hematopoietic stem cells can be difficult in patients with relapsed or refractory Hodgkin lymphoma (HL) who are candidates for autologous stem cell transplantation (ASCT). Plerixafor (AMD3100), an inhibitor of the interaction between stromal cell-derived factor 1 (SDF-1) and its receptor CXCR4, is an effective hematopoietic stem cell mobilization agent in patients with multiple myeloma and non-Hodgkin lymphoma (NHL). This study was undertaken to investigate the efficacy and safety of hematopoietic stem cell mobilization with plerixafor in patients with HL. Twenty-two patients with HL who were candidates for ASCT underwent hematopoietic stem cell mobilization with a combination of granulocyle-colony stimulating factor (G-CSF), 10 μg/kg daily, and plerixafor, 240 μg/kg subcutaneous, 10-11 hours prior to apheresis. The primary endpoint was the proportion of patients who collected ≥5 × 106 CD34+ cells/kg. Outcomes were compared to a historical control population of HL patients mobilized with G-CSF alone. Pharmacokinetic (PK) analysis of plerixafor was performed in a subset of patients. Fifteen patients (68%) collected ≥5 × 106 CD34+ cells/kg, and 21 patients (95%) achieved the minimum collection of ≥2 × 106 CD34+ cells/kg, in a median 2 apheresis procedures. Both the proportion of patients collecting ≥5 × 106 CD34+ cells/kg and the median CD34+ cells collected in days 1-2 of apheresis were significantly improved over historical controls. The PK of plerixafor in this patient population was similar to that previously seen in healthy volunteers. The regimen was generally safe and well tolerated.

Original languageEnglish
Pages (from-to)1253-1261
Number of pages9
JournalBiology of Blood and Marrow Transplantation
Volume14
Issue number11
DOIs
StatePublished - Nov 2008

Keywords

  • AMD3100
  • Hematopoietic stem cell mobilization
  • Hodgkin lymphoma
  • Plerixafor

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