A phase i trial of sunitinib and rapamycin in patients with advanced non-small cell lung cancer

Saiama N. Waqar, Priya K. Gopalan, Kristina Williams, Siddhartha Devarakonda, Ramaswamy Govindan

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Background: Sunitinib is an oral multitargeted tyrosine kinase inhibitor, with single-agent activity in non-small cell lung cancer (NSCLC). Resistance to tyrosine kinase inhibitor therapy is mediated by the mammalian target of rapamycin (mTOR) pathway, and may be reversed by using mTOR inhibitors. Methods: We performed a phase I study evaluating the combination of sunitinib and rapamycin in patients with advanced NSCLC. Results: Nineteen patients were enrolled in the study. The dose-limiting toxicities included infection, pneumonia, diarrhea/dehydration and treatment delay due to thrombocytopenia in 1 patient each. Sunitinib 25 mg orally daily and rapamycin 2 mg orally daily with 4 weeks on and 2 weeks off therapy were determined to be the maximum tolerated dose. No objective responses were noted, and 6 patients had stable disease as a best response. Conclusion: The combination of sunitinib and rapamycin is well-tolerated and warrants further investigation in the phase II setting.

Original languageEnglish
Pages (from-to)8-13
Number of pages6
JournalChemotherapy
Volume59
Issue number1
DOIs
StatePublished - Aug 2013

Keywords

  • Non-small cell lung cancer
  • Phase I trial
  • Rapamycin
  • Sunitinib

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