A phase 2 study of single agent ibrutinib for first-line treatment of chronic graft-versus-host disease: A new paradigm and lessons learned

Najla El Jurdi; Noa G. Holtzman; Rania Hishmeh; Alain Mina; Eduard Schulz; Anita Stokes; Grace Li; Keith T. Schmidt; William D. Figg; Nicholas Micheletti; Jacqueline W. Mays; Edward W. Cowen; Steven Z. Pavletic; Iskra Pusic

doi:10.1111/bjh.20069

A phase 2 study of single agent ibrutinib for first-line treatment of chronic graft-versus-host disease: A new paradigm and lessons learned

Najla El Jurdi
, Noa G. Holtzman
, Rania Hishmeh
, Alain Mina
, Eduard Schulz
, Anita Stokes
, Grace Li
, Keith T. Schmidt
, William D. Figg
, Nicholas Micheletti
, Jacqueline W. Mays
, Edward W. Cowen
, Steven Z. Pavletic
, Iskra Pusic

Research output: Contribution to journal › Letter › peer-review

Original language	English
Pages (from-to)	1822-1827
Number of pages	6
Journal	British Journal of Haematology
Volume	206
Issue number	6
DOIs	https://doi.org/10.1111/bjh.20069
State	Published - Jun 2025

Keywords

allogeneic haematopoietic cell transplantation
chronic graft-versus-host disease
front-line treatment
ibrutinib

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10.1111/bjh.20069

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El Jurdi, N., Holtzman, N. G., Hishmeh, R., Mina, A., Schulz, E., Stokes, A., Li, G., Schmidt, K. T., Figg, W. D., Micheletti, N., Mays, J. W., Cowen, E. W., Pavletic, S. Z., & Pusic, I. (2025). A phase 2 study of single agent ibrutinib for first-line treatment of chronic graft-versus-host disease: A new paradigm and lessons learned. British Journal of Haematology, 206(6), 1822-1827. https://doi.org/10.1111/bjh.20069

@article{e182276149ab4081b8c044bc87e850ea,

title = "A phase 2 study of single agent ibrutinib for first-line treatment of chronic graft-versus-host disease: A new paradigm and lessons learned",

keywords = "allogeneic haematopoietic cell transplantation, chronic graft-versus-host disease, front-line treatment, ibrutinib",

author = "\{El Jurdi\}, Najla and Holtzman, \{Noa G.\} and Rania Hishmeh and Alain Mina and Eduard Schulz and Anita Stokes and Grace Li and Schmidt, \{Keith T.\} and Figg, \{William D.\} and Nicholas Micheletti and Mays, \{Jacqueline W.\} and Cowen, \{Edward W.\} and Pavletic, \{Steven Z.\} and Iskra Pusic",

year = "2025",

month = jun,

doi = "10.1111/bjh.20069",

language = "English",

volume = "206",

pages = "1822--1827",

journal = "British Journal of Haematology",

issn = "0007-1048",

number = "6",

}

El Jurdi, N, Holtzman, NG, Hishmeh, R, Mina, A, Schulz, E, Stokes, A, Li, G, Schmidt, KT, Figg, WD, Micheletti, N, Mays, JW, Cowen, EW, Pavletic, SZ & Pusic, I 2025, 'A phase 2 study of single agent ibrutinib for first-line treatment of chronic graft-versus-host disease: A new paradigm and lessons learned', British Journal of Haematology, vol. 206, no. 6, pp. 1822-1827. https://doi.org/10.1111/bjh.20069

TY - JOUR

T1 - A phase 2 study of single agent ibrutinib for first-line treatment of chronic graft-versus-host disease

T2 - A new paradigm and lessons learned

AU - El Jurdi, Najla

AU - Holtzman, Noa G.

AU - Hishmeh, Rania

AU - Mina, Alain

AU - Schulz, Eduard

AU - Stokes, Anita

AU - Li, Grace

AU - Schmidt, Keith T.

AU - Figg, William D.

AU - Micheletti, Nicholas

AU - Mays, Jacqueline W.

AU - Cowen, Edward W.

AU - Pavletic, Steven Z.

AU - Pusic, Iskra

PY - 2025/6

Y1 - 2025/6

KW - allogeneic haematopoietic cell transplantation

KW - chronic graft-versus-host disease

KW - front-line treatment

KW - ibrutinib

UR - https://www.scopus.com/pages/publications/105004198703

U2 - 10.1111/bjh.20069

DO - 10.1111/bjh.20069

M3 - Letter

C2 - 40322855

AN - SCOPUS:105004198703

SN - 0007-1048

VL - 206

SP - 1822

EP - 1827

JO - British Journal of Haematology

JF - British Journal of Haematology

IS - 6

ER -

A phase 2 study of single agent ibrutinib for first-line treatment of chronic graft-versus-host disease: A new paradigm and lessons learned

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